Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Functional Roles of Exosomes in Allergic Contact Dermatitis

  • Bocui Song (Department of Pharmaceutical Engineering, College of Life Science and Technology, Heilongjiang Bayi Agricultural University) ;
  • Qian Chen (Molecular Mechanism of Disease and Research and Development of Bioactive Substances, College of Life Science and Technology, Heilongjiang Bayi Agricultural University) ;
  • Yuqi Li (Molecular Mechanism of Disease and Research and Development of Bioactive Substances, College of Life Science and Technology, Heilongjiang Bayi Agricultural University) ;
  • Shuang Zhan (Animal Husbandry and Veterinary Station of Yongji Economic Development Zone) ;
  • Rui Zhao (Department of Pharmaceutical Engineering, College of Life Science and Technology, Heilongjiang Bayi Agricultural University) ;
  • Xue Shen (Molecular Mechanism of Disease and Research and Development of Bioactive Substances, College of Life Science and Technology, Heilongjiang Bayi Agricultural University) ;
  • Min Liu (Department of Pharmaceutical Engineering, College of Life Science and Technology, Heilongjiang Bayi Agricultural University) ;
  • Chunyu Tong (Department of Biological Science, College of Life Science and Technology, Heilongjiang Bayi Agricultural University)
  • Received : 2022.06.16
  • Accepted : 2022.09.06
  • Published : 2022.12.28
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Abstract

Allergic contact dermatitis (ACD) is an allergen-specific T-cell-mediated inflammatory response, albeit with unclear pathogenesis. Exosomes are nanoscale extracellular vesicles secreted by several cell types and widely distributed in various biological fluids. Exosomes affect the occurrence and development of ACD through immunoregulation among other ways. Nevertheless, the role of exosomes in ACD warrants further clarification. This review examines the progress of research into exosomes and their involvement in the pathogenesis, diagnosis, and treatment of ACD and provides ideas for exploring new diagnostic and treatment methods for this disease.

Keywords

Acknowledgement

This research was supported by the National Nature Science Foundation of China (31702289), the Postdoctoral Scientific Research Start-up Fund of Heilongjiang (LBH-Q21158), the Key Research and Development Project of Heilongjiang Province of China (GZ20210101), the cultivation project of Heilongjiang Bayi Agricultural University (XDB-2016-22), the College Students' Innovation and Entrepreneurship Training Program in Heilongjiang Province: Inhibitory effect of gossypol on eotaxin in IgE mediated type I allergic reaction mice (201910223026).

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