Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach

  • Vahidi, Sogand (Medical Biology Research Center, Kermanshah University of Medical Sciences) ;
  • Mirzajani, Ebrahim (Department of Biochemistry, School of Medicine, Guilan University of Medical Sciences) ;
  • Norollahi, Seyedeh Elham (Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences) ;
  • Aziminezhad, Mohsen (Non-Communicable Disease Research Center, Neyshabur University of Medical Sciences) ;
  • Samadani, Ali Akbar (Guilan Road Trauma Research Center, Guilan University of Medical Sciences)
  • Received : 2021.07.29
  • Accepted : 2022.04.11
  • Published : 2022.06.30
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Abstract

Gastric cancer (GC) is a significant cause of cancer mortality which has led to focused exploration of the pathology of GC. The advent of genome-wide analysis methods has made it possible to uncover genetic and epigenetic fluctuation such as abnormal DNA methylation in gene promoter regions that is expected to play a key role in GC. The study of gastric malignancies requires an etiological perspective, and Helicobacter pylori (H. pylori) was identified to play a role in GC. H. pylori infection causes chronic inflammation of the gastric epithelium causing abnormal polyclonal methylation, which might raise the risk of GC. In the last two decades, various pathogenic factors by which H. pylori infection causes GC have been discovered. Abnormal DNA methylation is triggered in several genes, rendering them inactive. In GC, methylation patterns are linked to certain subtypes including microsatellite instability. Multiple cancer-related processes are more usually changed by abnormal DNA methylation than through mutations, according to current general and combined investigations. Furthermore, the amount of acquired abnormal DNA methylation is heavily linked to the chances of developing GC. Therefore, we investigated abnormal DNA methylation in GC and the link between methylation and H. pylori infection.

Keywords

Acknowledgement

Authors express their appreciation to all people who contributed to this manuscript.

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