Korean Journal of Psychosomatic Medicine (정신신체의학)

Korean Psychosomatic Society (한국정신신체의학회)
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Relationships Between Premonitory Urge, Tics and Comorbidities in Children and Adolescents With Chronic Tics

만성 틱장애 소아청소년의 전조충동, 틱증상 심각도, 동반질환 간의 관련성

  • Joo-Han Kwon (Department of Psychiatry, Jeonbuk National University Hospital) ;
  • Sang-Keun Chung (Department of Psychiatry, Jeonbuk National University Hospital) ;
  • Jong-Chul Yang (Department of Psychiatry, Jeonbuk National University Hospital) ;
  • Jong-Il Park (Department of Psychiatry, Jeonbuk National University Hospital) ;
  • Ha-Min Kim (Wee Center, Jeonbuk National University Hospital) ;
  • Tae Won Park (Department of Psychiatry, Jeonbuk National University Hospital)
  • 권주한 (전북대학교병원 정신건강의학과) ;
  • 정상근 (전북대학교병원 정신건강의학과) ;
  • 양종철 (전북대학교병원 정신건강의학과) ;
  • 박종일 (전북대학교병원 정신건강의학과) ;
  • 김하민 (전북대학교병원 Wee센터) ;
  • 박태원 (전북대학교병원 정신건강의학과)
  • Received : 2023.11.06
  • Accepted : 2023.12.25
  • Published : 2023.12.31
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Abstract

Objectives : The purpose of this study is to investigate the relationships between premonitory urge, tic severity, and comorbidities in children and adolescents with chronic tic disorders. Methods : In this study, scales for tic symptoms, premonitory urge, obsessive-compulsive symptoms, and ADHD symptoms were repeatedly measured twice in 26 children and adolescents aged 10 to 18 years with chronic tic disorders. Correlations between scales were confirmed through repeated measures correlation analysis, and causal relationships between scales were confirmed through regression analysis using a linear mixed model. Results : The degree of premonitory urges showed a significant positive correlation with the severity of tic symptoms, the severity of obsessive-compulsive symptoms, and the severity of ADHD symptoms. The ADHD symptoms showed a significant positive correlation with the severity of tic symptoms. These results were the same even in children and adolescents with tic disorders who were not diagnosed with obsessive-compulsive disorder. Additionally, premonitory urges were found to have a significant positive effect on the severity of tic symptoms. Conclusions : These results may be helpful in treating tic disorders and can be used in future tic disorder research considering developmental trajectory.

연구목적 본 연구는 틱장애 소아청소년들을 대상으로 틱증상 심각도, 전조 충동, 강박증상, 주의력결핍과잉행동 증상을 종단적으로 평가하여 틱장애의 임상적 특성을 알아보기 위해 시행하였다. 방 법 본 연구는 10-18세 소아청소년 26명을 대상으로 틱증상, 전조충동, 강박증상, ADHD 증상에 관한 척도를 2차례 반복 측정 하였다. 반복 측정 상관 분석(repeated measures correlation analysis)을 통해 척도간 상관관계를 확인하였고 선형 혼합 모형(linear mixed model)을 이용한 회귀 분석을 통해 척도간 인과관계를 확인하였다. 결 과 틱장애 소아청소년들에서 전조충동은 틱증상 정도, 강박증상 정도, 주의력결핍과잉행동 증상 정도와 각각 유의한 양의 상관관계를 보였고 주의력결핍과잉행동 증상은 틱증상 심각도와 유의한 양의 상관관계를 나타냈다. 이러한 결과는 강박장애를 공존질환으로 진단 받지 않은 틱장애 소아청소년들에서도 같았다. 또한 전조충동은 틱증상의 심각도에 유의한 양의 영향을 미치는 것으로 나타났다. 결 론 이러한 결과는 틱장애 치료에 도움이 될 수 있으며 향후 발달 경로를 고려한 틱장애 연구에 활용될 수 있다.

Keywords

Acknowledgement

이 논문은 전북대학교병원 의생명연구원의 학술연구비 지원에 의하여 연구되었음.

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