Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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The Anti-inflammatory Mechanism of Pu-erh Tea via Suppression the Activation of NF-κB/HIF-1α in LPS-stimulated RAW264.7 Cells

  • Su-Jin Kim (Division of Cosmetic Science & Technology, Daegu Haany University)
  • Received : 2023.05.08
  • Accepted : 2023.06.26
  • Published : 2023.06.30
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Abstract

Pu-erh tea, a popular and traditional Chinese tea, possesses various health-promoting effects, including inhibiting tumor cell progression and preventing type II diabetes and neurodegenerative disorders. However, the precise anti-inflammatory mechanisms are not well understood. In present study, we elucidated the anti-inflammatory mechanism of Pu-erh tea in lipopolysaccharide (LPS)-activated RAW264.7 cells. We explored the effects of Pu-erh tea on the levels of inflammatory-related genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) in LPS-activated RAW264.7 cells. Moreover, we investigated its regulatory effects on nuclear factor-kappa B (NF)-κB and hypoxia-inducible-factor (HIF)-1α activation. The findings of this study demonstrated that Pu-erh tea inhibited the LPS-increased inflammatory cytokines and PGE2 release, as well as COX-2 and iNOS expression. Moreover, we confirmed that the anti-inflammatory mechanism of Pu-erh tea occurs via the inhibition of NF-κB and HIF-1α activation. Conclusively, these findings provide experimental evidence that Pu-erh tea may be useful candidate in the treatment of inflammatory-related diseases.

Keywords

Acknowledgement

This research was supported by "Kuaihuo Puercha" Institute. This research was supported by Basic Science Research Program through the NRF funded by the Ministry of Education (NRF-2021R1F1A1047814).

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