The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Review on the Effects of Herbal Medicine on Respiratory Diseases in In Vivo Particulate Matter Models

미세먼지 in vivo 모델에서 호흡기 질환에 대한 한약의 효과에 관한 연구 동향 분석

  • Seong-cheon Woo (Division of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Dae-Jeon University) ;
  • Su-won Lee (Division of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Dae-Jeon University) ;
  • Yang-chun Park (Division of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Dae-Jeon University)
  • 우성천 (대전대학교 한의과대학 폐계내과학교실) ;
  • 이수원 (대전대학교 한의과대학 폐계내과학교실) ;
  • 박양춘 (대전대학교 한의과대학 폐계내과학교실)
  • Received : 2023.05.19
  • Accepted : 2023.06.23
  • Published : 2023.06.30
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Abstract

Objective: This study was conducted to review the effects of herbal medicine on respiratory diseases induced by the treatment of particulate matter in in vivo animal models. Methods: Literature searches were performed in seven databases (Pubmed, Embase, Cochrane Library, KISS, KTKP, OASIS, and ScienceON). After the searched studies were screened based on the inclusion/exclusion criteria, the publication date, origin, used animals, induction of particulate matter models, herbal medicine used for intervention, study design, outcome measure, and results of studies were analyzed. Results: Among a total of 972 studies primarily searched, 34 studies were finally included in our study. Of this number, 29 studies induced animal models by using only particulate matter, and 5 studies induced animal models with respiratory diseases, such as asthma and chronic obstructive pulmonary disease, by using particulate matter and other materials. In the selected studies, the treatments of herbal medicine in particulate matter models suppressed oxidative stress and inflammation in lung tissue, bronchoalveolar lavage fluid, and blood as well as lung injury in histological analysis. Conclusion: The results of this study suggest that herbal medicine is effective in treating respiratory diseases induced by particulate matter. These results are also expected to be useful data for designing further studies. However, more systematically designed in vivo studies related to particulate matter are needed.

Keywords

Acknowledgement

이 논문은 2022학년도 대전대학교 교내학술연구비 지원에 의해 연구되었음.

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