DOI QR코드

DOI QR Code

Safety Effect of Cosmetics Containing Coptis Japonica Extract on Sensitive Skin

황련 추출물을 함유한 화장품의 민감성 피부 안전성 연구

  • Kyung Nam Min (Department of Cosmetics Inventive Design, Anyang University)
  • 민경남 (안양대학교 화장품발명디자인학과)
  • Received : 2023.05.05
  • Accepted : 2023.06.23
  • Published : 2023.06.30

Abstract

This study was to verify the skin safety of Coptis Japonica extract(CJE) -containing cosmetics by patching them on sensitive skin and checking its stimulating level. 32 subjects diagnosed with sensitive skin by the result of the lactic acid injury test, were subjected to 20 ㎕ of solubilized essence mixed with 2% CJE on the test subjects' back and closed patched for 24 hours. No stimulus reactions were found by bare eyes and scored 0 stimulus figure points after they were taken off in 30 minutes, 24 hours, and 48 hours. Coptis japonica's medical efficacies such as antioxidant, and anti-inflammatory are expectable to be used as functional cosmetics, and this research would be the foundation of further research into its cosmetical usage.

황련(Coptis Japonica)의 뿌리로 제조한 황련 추출물 화장품이 민감한 피부에도 안전한지 검증하기 위해 민감성 피부를 대상으로 인체 첩포 시험을 실시하였다. 젖산 자상 검사 결과 민감성 피부로 판정한 총 32명의 시험대상자에게 황련 추출물을 2% 배합한 가용화 에센스를 시험대상자 등 부위에 20 ㎕ 취하여 24 h 동안 폐쇄 첩포한 후 이를 제거하고 30 min과 24 h 후의 시험 부위를 피부과 전문의가 육안으로 관찰하여 피부 자극 지수를 산출하였다. 그 결과 육안으로 이상 반응이 확인되지 않았고 자극 지수가 총 0점으로 나타나 황련 추출물 2%를 배합한 화장품이 민감한 피부에 안전한 것을 확인하였다. 다수의 황련 연구에서 항균, 항산화, 항염 등의 활성이 밝혀지고 화장품 소재로 이용 가능성이 보고되고 있지만 본 연구를 통해 황련 추출물 화장품이 민감한 피부에도 안전한 것으로 나타나 향후 황련 화장품의 무자극 또는 저자극의 소재연구에서 본 연구가 기초 자료로 활용될 것으로 기대된다.

Keywords

References

  1. S. H. Moon, S. S. Han, Y. H. Kim, W. K. Yoo, K. H. Kim, "Cosmetic safety awareness: a comparison between general consumers and skin care workers", J Invest Cosmetol, Vol.4, No.3 pp. 343-350, (2018).
  2. H. H. Kang, "Well-being in cosmetics", Journal of the Society of Cosmetic Scientists of Korea, Vol.30, No.307 pp. 307-311, (2004).
  3. L. Luo, J. Nong Wang, L. D. Kong, Q.. C. Jiang, R. X. Tan, "Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formual", J. Ethnopharmacol, Vol.73, pp. 277-281, (2000). https://doi.org/10.1016/S0378-8741(00)00242-7
  4. K. S. Kang, "The evaluation of anti-wrinkle effects in oriꠓental herb extract", Journal of Life Science, Vol.17, No.8 pp. 1147-1151, (2007). https://doi.org/10.5352/JLS.2007.17.8.1147
  5. D. E. Pratt, P. M. Birac, "Source of antioxidant activity of Soybeans and soy products", Journal of Food Science, Vol.44, pp. 1720-1722, (1979). https://doi.org/10.1111/j.1365-2621.1979.tb09125.x
  6. G. Block, L. Langseth, "Antioxidant vitamins and disease prevention", Journal of Food Technology, Vol.48, No.7 pp. 80-84, (1994).
  7. W. S. Woo, "Natural Product Chemistry Research Act", Seoul National University Press, Vol.32 (2001).
  8. J. J. Cho, K. K. Lee, B. K. Jo, J. D. Choi, "Isolation and characterization of elastse inhibitor from Areca catechu", Journal of the Society of Cosmetic Scientists of Korea, Vol.26, No.1 pp. 163-185, (2000).
  9. Y. J. Ji, J. W. Lee, I. S. Lee, "Antimicrobial effect of medicinal plants against methicllin-resistant Staphylococcus aureus (MRSA)", Journal of Life Science, Vol.17, No.3 pp. 412-419, (2007). https://doi.org/10.5352/JLS.2007.17.3.412
  10. B. S. Kim, "Antifungal activity of Zanthaxylum schinifolium against Fusarium graminearum, a barley powdery mildew fungus", Journal of Life Science, Vol.18, No.7 pp. 974-979, (2008). https://doi.org/10.5352/JLS.2008.18.7.974
  11. E. H. Kim, Y. A. Jang, S. B. Kim, H.. H. Kim, J. T. Lee, "Antimicrobial, antifungal effect and safety verification using BCOP assay of extracts from Coptis chinensis", Journal of Applied Biological Chemistry, Vol.61, No.3 pp. 297-304, (2018). https://doi.org/10.3839/jabc.2018.042
  12. U. K. Seo, J. I. Shin, "Antibacterial effects of Corptis japonica against Helicobacter pylori", The journal of internal Korean medicine, Vol.24, No.2 pp. 269-282, (2003).
  13. Y. A. Jang, B. O. Kim, J. S. Chung, H. J. Hwang, J. T. Lee, "A Study on the Antimicrobial Activity and the Pharmacological Activities of matrial Isolated from Coptis Radix", Journal of oil & applied science, Vol.34, No.2 pp. 271-279, (2017).
  14. J. S. Eum, "Antimicrobial Activity of Coptis chinensis and Sophora flavescens against Streptococcus mutans ATCC 25175", Journal of the Korea Institute of Information and Communication Engineering, Vol.16, No.2 pp. 384-389, (2012). https://doi.org/10.6109/jkiice.2012.16.2.384
  15. J. H. Bae, "Antimicrobial Effect of Plagiorhegama dubium Extracts on Foodborne Pathogen", The Korean journal of food and nutrition, Vol.18, No.1 pp. 81-87, (2005).
  16. Y. J. Kim, M. J. Lee, J. W. Park, J. K. Kim, D. Y. Choi, C. H. Kim, "Antioxidant Activity of Water-Extract from Coptis chinensis Franch", Journal of life science, Vol.10, No.3 pp. 241-246, (2000).
  17. S. R. Oh, "Anti-aging and Anti-oxidative Effect of Naesohwangryun-tang(NSHRT)", The Journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Vol.34, No.4 pp. 12-23, (2021).
  18. H. P. Gi, S. I. Jang, Y. G. Yoon, "Ameliorative Effects of Hwangnyeonhaedok-tang on Atopic Dermatitis", Herbal formula science, Vol.21, No.1 pp. 80-90, (2013). https://doi.org/10.14374/HFS.2013.21.1.080
  19. A. R. Jung, S. H. Ahn, H. S Jeong, G. B. Kim, "Effect of Coptidis Rhizoma extract on Atopic Dermatitis-like Skin Lesions in NC/Nga Mice", Journal of physiology & pathology in Korean Medicine, Vol.33, No.2 pp. 102-108, (2019). https://doi.org/10.15188/kjopp.2019.04.33.2.102
  20. J. W. Lee, H. H. Han, Y. J. Lee, "Anti-inflammatory Effect of Coptidis Rhizoma Extract", The Korea journal of herbology, Vol.29, No.5 pp. 83-90, (2014). https://doi.org/10.6116/kjh.2014.29.5.83
  21. Y. A. Lee, "Anti-inflammatory Effects the Coptis chinensis Extract.", Journal of kyung hee university medical center, Vol.23, No.1 pp. 21, (2007).
  22. E. H. Kim, Y. R. Moon, Y. A. Jang, "Moisturizing Properties and Anti-Inflammatory effects of extracts from Coptis chinensis in HaCaT cells", Journal of the Korean Applied Science and Technology, Vol.38, No.3 pp. 870-882, (2021).
  23. J. K. Choi, Y. J. Huh, W. I. Lee, Y. K. Kim, T. H. Lee, M. S. Oh, "Anti-inflammatory effects of Coptidis Rhizoma in chronic cold stress-exposed mice", The Korea journal of herbology, Vol.33, No.6 pp. 35-42, (2018). https://doi.org/10.6116/KJH.2018.33.6.35
  24. G. R. Yun, Y. J. Kim, E. Lee, J. M. Lee, "Anti-inflammatory Effect of Coptidis Rhizoma", The Korea journal of herbology, Vol.24, No.3 pp. 79-86, (2009). https://doi.org/10.6116/KJH.2009.24.3.079
  25. E. H Jo, T. H Lee, "Effects of Coptidis Rhizoma and Aconiti Lateralis Preparata Radix on the Change of Plasma Corticosterone Level and Rectal Temperature Induced by LPS", The Korea journal of herbology, Vol.21, No.2 pp. 77-85, (2006).
  26. J. G. Lee, S. J Park, S. C. Kim, S. Y. Ji, "Coptidis Rhizoma Extract induces Apoptotic Cell Death in YD-10B Cell", The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Vol.22, No.2 pp. 50-59, (2009).
  27. E. C. Kim, S. H. Kim, J. H. Lee, T. J. Kim, "Antiangiogenic Activity of Coptis chinensis Franch. Water Extract in in vitro and ex vivo Angiogenesis Models", Journal of life science, Vol.27, No.1 pp. 78-88, (2017). https://doi.org/10.5352/JLS.2017.27.1.78
  28. S. D. Kim, K. H. Kim, H. M. Sin, "Effects of Cnidium officinale, Petasites japonicus, Coptis chinensis Extract Mixture on Vasodilation", Journal of physiology & pathology in Korean Medicine, Vol.20, No.6 pp. 1620-1624, (2006).
  29. P. J. Frosch, A. M. Kligman, "The soap chamber; a new method for assessing the irritancy", Journal of American Academy Dermatol, Vol.1, No.1 pp. 35-41, (1979). https://doi.org/10.1016/S0190-9622(79)70001-6