Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Association between Mild Cognitive Impairment and Gut Microbiota in Elderly Korean Patients

  • Eun-Ju Kim (Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University) ;
  • Jae-Seong Kim (Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University) ;
  • Seong-Eun Park (Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University) ;
  • Seung-Ho Seo (Sonlab Inc.) ;
  • Kwang-Moon Cho (AccuGene Inc.) ;
  • Sun Jae Kwon (AccuGene Inc.) ;
  • Mee-Hyun Lee (College of Korean Medicine, Dongshin University) ;
  • Jae-Hong Kim (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Hong-Seok Son (Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University)
  • Received : 2023.05.10
  • Accepted : 2023.06.11
  • Published : 2023.10.28
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Abstract

Recent studies have confirmed that gut microbiota differs according to race or country in many diseases, including mild cognitive impairment (MCI) and Alzheimer's disease. However, no study has analyzed the characteristics of Korean MCI patients. This study was performed to observe the association between gut microbiota and MCI in the Korean elderly and to identify potential markers for Korean MCI patients. For this purpose, we collected fecal samples from Korean subjects who were divided into an MCI group (n = 40) and control group (n = 40) for 16S rRNA gene amplicon sequencing. Although no significant difference was observed in the overall microbial community profile, the relative abundance of several genera, including Bacteroides, Prevotella, and Akkermansia, showed significant differences between the two groups. In addition, the relative abundance of Prevotella was negatively correlated with that of Bacteroides (r = 0.733). This study may provide Korean-specific basic data for comparing the characteristics of the gut microbiota between Korean and non-Korean MCI patients.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (No. 2022R1A5A2029546 and 2021R1A2C2007041), a Korea University Grant, and the Institute of Biomedical Science and Food Safety, CJ-Korea University Food Safety Hall at Korea University, Republic of Korea.

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