Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Effects of Neuromuscular Electrical Stimulation on Muscle Wasting with Cancer Patient: A Systematic Review

신경근전기자극치료가 암 환자의 근육 손실에 미치는 영향: 체계적 문헌고찰

  • Eun Soo Park (Clinical Trial Center, Daejeon Korean Medicine Hospital, Daejeon University) ;
  • Jong Hee Kim (Clinical Trial Center, Daejeon Korean Medicine Hospital, Daejeon University) ;
  • Soo Dam Kim (KM Science Research Division, Korea Institute of Oriental Medicine) ;
  • Dong Hyun Kim (National Clinical Research Center of Korean Medicine, Korean Medicine Hospital, Pusan University) ;
  • Eun Jung Lee (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University) ;
  • Min Seok Oh (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University) ;
  • Hwa Seung Yoo (Clinical Trial Center, Daejeon Korean Medicine Hospital, Daejeon University)
  • 박은수 (대전대학교 대전한방병원 임상시험센터) ;
  • 김종희 (대전대학교 대전한방병원 임상시험센터) ;
  • 김수담 (한국한의학연구원 한의과학연구부) ;
  • 김동현 (부산대학교 한방병원 한의약 임상연구센터) ;
  • 이은정 (대전대학교 한의과대학 한방재활의학교실) ;
  • 오민석 (대전대학교 한의과대학 한방재활의학교실) ;
  • 유화승 (대전대학교 대전한방병원 임상시험센터)
  • Received : 2023.09.22
  • Accepted : 2023.10.20
  • Published : 2023.10.31
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Abstract

Objectives The purpose of this study is to systematically review the effects of Neuromuscular Electrical Stimulation treatment on muscle wasting in cancer patients. Methods Randomized controlled trials (RCTs) were searched from seven online databases (PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, Research Information Sharing Service. The selected RCTs were evaluated for methodological quality through the Cochrane RoB. Results A total of 126 articles were identified, and 4 randomized controlled trials were selected for systematic review. In one study, it was found that there were statistically significant improvements in the Health-Related Quality of Life (FACTH&N total score, p<0.001). Additionally, significant effects were observed in measurements that represented the size of the quadriceps muscle (cross-sectional area of Vastus lateralis and Rectus femoris, p=0.004), maximum muscle strength, the twitch response of resistance muscles, and voluntary activation (p<0.001). However, no significant differences were observed between the intervention and control groups in terms of quadriceps muscle strength in two other studies (p>0.05). Lastly, while one study showed no significant differences in muscle fiber characteristics between the two groups, it did report significant improvements in measurements related to mitochondria within muscle tissue and muscle strength in the intervention group (p<0.05). Conclusions Neuromuscular electrical stimulation can be a method used to improve muscle strength in muscle wasting of cancer patients, but it is difficult to see its effects as significant compared to other treatments.

Keywords

Acknowledgement

This study was supported by the 2022 Startup and Commercialization Support Project of the Ministry of SMEs and Startups (Project No. 20052267).

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