DOI QR코드

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RNA FOLDINGS AND STUCK KNOTS

  • 투고 : 2022.12.13
  • 심사 : 2023.09.18
  • 발행 : 2024.01.31

초록

We study RNA foldings and investigate their topology using a combination of knot theory and embedded rigid vertex graphs. Knot theory has been helpful in modeling biomolecules, but classical knots emphasize a biomolecule's entanglement while ignoring their intrachain interactions. We remedy this by using stuck knots and links, which provide a way to emphasize both their entanglement and intrachain interactions. We first give a generating set of the oriented stuck Reidemeister moves for oriented stuck links. We then introduce an algebraic structure to axiomatize the oriented stuck Reidemeister moves. Using this algebraic structure, we define a coloring counting invariant of stuck links and provide explicit computations of the invariant. Lastly, we compute the counting invariant for arc diagrams of RNA foldings through the use of stuck link diagrams.

키워드

과제정보

The authors would like to thank the referee for the fruitful comments which improved the paper. The authors would also like to thank Willi Kepplinger for his comments on an earlier version of this article.

참고문헌

  1. K. Bataineh, Stuck knots, Symmetry 12 (2020), no. 9, 1558. 
  2. K. Bataineh, M. Elhamdadi, M. Hajij, and W. Youmans, Generating sets of Reidemeister moves of oriented singular links and quandles, J. Knot Theory Ramifications 27 (2018), no. 14, 1850064, 15 pp. https://doi.org/10.1142/S0218216518500645 
  3. J. Ceniceros, I. R. Churchill, and M. Elhamdadi, Polynomial invariants of singular knots and links, J. Knot Theory Ramifications 30 (2021), no. 1, Paper No. 2150003, 17 pp. https://doi.org/10.1142/S0218216521500036 
  4. J. Ceniceros, I. R. Churchill, and M. Elhamdadi, Singquandle shadows and singular knot invariants, Canad. Math. Bull. 65 (2022), no. 3, 770-787. https://doi.org/10.4153/S0008439521000837 
  5. J. Ceniceros, I. R. Churchill, M. Elhamdadi, and M. Hajij, Cocycle invariants and oriented singular knots, Mediterr. J. Math. 18 (2021), no. 5, Paper No. 217, 17 pp. https://doi.org/10.1007/s00009-s021-s01867-s6 
  6. M. Elhamdadi and S. Nelson, Quandles-an introduction to the algebra of knots, Student Mathematical Library, 74, Amer. Math. Soc., Providence, RI, 2015. https://doi.org/10.1090/stml/074 
  7. D. Joyce, A classifying invariant of knots, the knot quandle, J. Pure Appl. Algebra 23 (1982), no. 1, 37-65. https://doi.org/10.1016/0022-s4049(82)90077-s9 
  8. L. H. Kauffman, State models and the Jones polynomial, Topology 26 (1987), no. 3, 395-407. https://doi.org/10.1016/0040-s9383(87)90009-s7 
  9. L. H. Kauffman and Y. B. Magarshak, Vassiliev knot invariants and the structure of RNA folding, in Knots and applications, 343-394, Ser. Knots Everything, 6, World Sci. Publ., River Edge, NJ, 1995. https://doi.org/10.1142/9789812796189_0009 
  10. A. Mashaghi, R. J. van Wijk, and S. J. Tans, Circuit topology of proteins and nucleic acids, Structure 22 (2014), no. 9, 1227-1237. 
  11. S. Matveev, Distributive groupoids in knot theory, Mat. Sb. (N.S.) 119(161) (1982), no. 1, 78-88, 160. 
  12. N. Oyamaguchi, Enumeration of spatial 2-bouquet graphs up to flat vertex isotopy, Topology Appl. 196 (2015), part B, 805-814. https://doi.org/10.1016/j.topol.2015.05.049 
  13. M. Polyak, Minimal generating sets of Reidemeister moves, Quantum Topol. 1 (2010), no. 4, 399-411. https://doi.org/10.4171/QT/10 
  14. J. I. Sulkowska, E. J. Rawdon, K. C. Millett, J. N. Onuchic, and A. Stasiak, Conservation of complex knotting and slipknotting patterns in proteins, Proceedings of the National Academy of Sciences 109 (2012), no. 26, E1715-E1723, available at https://www.pnas.org/doi/pdf/10.1073/pnas.1205918109. 
  15. W. Tian, X. Lei, L. H. Kauffman, and J. Liang, A knot polynomial invariant for analysis of topology of RNA stems and protein disulfide bonds, Mol. Based Math. Biol. 5 (2017), 21-30. https://doi.org/10.1515/mlbmb-s2017-s0002 
  16. V. A. Vasilev, Cohomology of spaces of knots, Akad. Nauk SSSR Inst. Prikl. Mat. Preprint 91 (1990), 29 pp.