The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Ferroptosis and its role in gastric and colorectal cancers

  • Jinxiu Hou (School of Anesthesiology, Weifang Medical University) ;
  • Bo Wang (School of Anesthesiology, Weifang Medical University) ;
  • Jing Li (Department of Gastroenterology, Weifang People's Hospital) ;
  • Wenbo Liu (Central Laboratory, The First Affiliated Hospital of Weifang Medical University)
  • Received : 2023.10.18
  • Accepted : 2023.12.05
  • Published : 2024.05.01
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Abstract

Ferroptosis is a novel mechanism of programmed cell death, characterized by intracellular iron overload, intensified lipid peroxidation, and abnormal accumulation of reactive oxygen species, which ultimately resulting in cell membrane impairment and demise. Research has revealed that cancer cells exhibit a greater demand for iron compared to normal cells, indicating a potential susceptibility of cancer cells to ferroptosis. Stomach and colorectal cancers are common gastrointestinal malignancies, and their elevated occurrence and mortality rates render them a global health concern. Despite significant advancements in medical treatments, certain unfavorable consequences and drug resistance persist. Consequently, directing attention towards the phenomenon of ferroptosis in gastric and colorectal cancers holds promise for enhancing therapeutic efficacy. This review aims to elucidate the intricate cellular metabolism associated with ferroptosis, encompassing lipid and amino acid metabolism, as well as iron metabolic processes. Furthermore, the significance of ferroptosis in the context of gastric and colorectal cancer is thoroughly examined and discussed.

Keywords

Acknowledgement

Funding for scientific research: 02196801.

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