• Biomedical Science Letters
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• v.24 no.2
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• pp.64-75
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• 2018

CCN3 (also known as NOV, Nephroblastoma overexpressed) proteins are involved in various pathologies during different developmental stages. We have previously shown that intracellular levels and normal extracellular secretion of CCN3 are important for neuronal differentiation. Furthermore, we demonstrated that a single amino acid in the CCN3 TSP-1 domain is important for extracellular secretion and that palmitoylation of CCN3 is required in this process. However, the effect of abnormal CCN3 accumulation on cells remains to be studied. Here, we found mutations in the TSP-1 domain of CCN3 that led to intracellular accumulation and abnormal aggregation of CCN3. It was observed that this mutation resulted in a phenomenon similar to neurodegeneration when overexpressed in the developing mouse cortex. This mutation also confirmed the activation of apoptotic gene expression in Neuro2a cells. In addition, we confirmed the in vivo transcriptional changes induced by this mutation using microarray analysis. We observed a significant increase in the expression of Anp32a, an apoptosis-related gene. Collectively, these results indicate that a single mutation in CCN3 can lead to abnormal cell death if it shows intracellular accumulation and abnormal aggregation.

• Journal of Acupuncture Research
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• v.21 no.4
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• pp.1-18
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• 2004

Objective : This study was performed to investigate the effects of aqua-acupuncture of Jibaikjihwangtang in two-kidney one clip Goldblatt hypertensive rats and spontaneously hypertensive rats. Methods : we injected aqua-acupuncture solution into Shin-Soo ($BL_{23}$) which corresponds to human acupuncture point in two-kidney one clip Goldblatt hypertensive rats and spontaneously hypertensive rats. Systolic blood pressure, renin activity, aldosterone and atrial natriuretic peptide (ANP) plasma levels were tested. Results : Systolic blood pressure decreased significantly after aqua-acupuncture of jibaikjihwangtang. Acupuncture group in two-kidney one clip Goldblatt hyper-tensive rats had deference with control group. In plasma levels of atrial natriuretic peptide, acupuncture group of spontaneously hypertensive rats increased meaningfully but to two-kidney one clip Goldblatt hypertensive rats it was decreased meaningfully. In Serum Aldosterone density, the acupuncture group of spontaneously hypertensive rats had significant alteration than control group, but the acupuncture group of two-kidney one clip Goldblatt hypertensive rats had decreased alteration than control group. Conclusion : According to these results, after Aqua-Acupuncture of Jibaikjihwangtang blood pressure decreased significantly and data suggest that blood pressure reduction activity connected with renin activity reduction in renal hypertensive rat.

• International Journal of Quality Innovation
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• v.9 no.2
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• pp.99-117
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• 2008

High-tech industry has been the principal economic source for Taiwan in recent years. The characteristics of high-tech industries in Taiwan are changeable product markets, short product life cycles and high company attrition rate. In the globalization trend, the high-tech industry has gradually increased corporate competitiveness and reached the goal of sustainable operations through knowledge management, knowledge sharing and new product research and development. Firms have aggressively strengthened and integrated their internal and external resources and enhanced knowledge sharing to increase industry operational performance. Effectively strengthening the knowledge management operation and performance evaluation of knowledge sharing in Taiwan's high-tech industry has become a critical issue. In the selection of knowledge sharing Key Performance Indicators (KPI), this research divided the knowledge sharing indicators into representative strategic indicators such as organizational knowledge learning, organizational knowledge resources, organizational information capacity and organizational knowledge performance through screening using Factor Analysis. The characteristics of the constructs were interdependent. This research calculated and adjusted the correlation among the key performance knowledge sharing indicators using ANP and determined the relative weight of knowledge sharing.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.05b
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• pp.1307-1311
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• 2005

최근들어 Water Security에 대한 관심이 고조되고 있지만 국내의 경우 이에 대한 체계적인 연구가 아직 진행되지 않았고 상수도관망시스템의 오염예방 및 위험관리에 대한 연구는 매우 미비한 실정이며 특히 상수도관망시스템의 위험성 및 취약성에 대한 연구는 전무한 상태이다. 이러한 상수도관망시스템의 위험도와 관련된 여러 위험요소들은 인명의 피해, 재산상의 피해, 환경적 피해, 시스템의 피해 그리고 사회적 불안등 여러 기준을 고려하여 평가되어야 한다. 이 문제는 다기준의사결정(multi-criteria decision making)문제로서 평가기준들(criteria) 간의 상충관계(trade-off)로 인하여 판단이 모호한 대안들을 PROMETHEE(Preference Ranking Organization METHod Enrichment Evaluations) 기법을 이용하여 평가하였다. PROMETHEE는 선호의 유출량(leaving flow)과 유입량(entering flow)의 개념을 이용하여 여러 대안들의 순위선호(outranking)를 산정하는 기법으로, 의사결정자(decision matter)가 비교적 쉽게 이해할 수 있으며 기존의 AHP$\cdot$ANP와는 달리 명확한 판단이 어려운 대안들에 대해서는 비교불가능한(incomparable) 대안으로 분류한다. 이와 같은 위험도 평가결과는 위기상황에 대한 대처방안을 제시할 의사결정시스템 구축의 기초 자료가 될 수 있을 것이다.

• International Journal of Highway Engineering
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• v.14 no.6
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• pp.93-101
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• 2012

PURPOSES : This study is to develop ISM for potential risk factor in School Zone. METHODS : Based on the literature review, the Analytic Hierarchy Process (AHP) has been used most widely. However, it is difficult to apply in practice because the AHP results have the characteristics of the independence between each element and the interlayer can not explain the interrelationship. The Network Analysis Process (ANP) is possible to analyze the relationship between the elements and the network through the feedback. But, the reliability of the analysis fall because of complicated pair of comparison, also it is difficult to solve the super matrix. In this study, the complicated relationship between each element is inquired through the Interpretive Structural Modeling (ISM). RESULTS : The methodology of ISM is developed to remove the children's potential risk factors in school zone. CONCLUSIONS : It is possible to remove the children's potential risk factors from low level to high level step by step and improve safety. Through this, risk factors can be removed from the low-level, and upper-level will automatically improve.

• The Journal of Korean Medicine
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• v.17 no.1 s.31
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• pp.329-335
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• 1996

Rehmannia Radix is a thick tuberous root about 3-6 cm diameter. The tuberous root is repared for medicine. The material in the fresh state is shengdihuang (生地黃). The material in the dried state is gandihuang (乾地黃). Shudihuang (熱地黃) is made by taking juicy roots, washing them in millet wine, steaming on a willow frame in a percelain vessel, drying, and resteaming and redrying nine times. The aim of this experiments was to investigate the effect of Rehmannia Radix Water extracts on the plasma renin activity and plasma levels of aldosterone and atrial natriuretic peptide (ANP) in rats. The results of study were as follows: Plasma renin activity was not changed after administration of Rehmannia Radix water extracts. Plasma levels of aldosterone was decreased significantly after administration of Shudihuang (熱地黃) water extracts. Plasma levels of atrial natriuretic peptide was increased significantly after administration of Shudihuang (熱地黃) water extracts.

• Journal of the Korean housing association
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• v.20 no.6
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• pp.127-134
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• 2009

This study initially analyzes the meaning of Community-Based Residential Environment Improvement. A residential environment improvement factor was determined through an analysis of the function, components, Planning techniques of the community, the evaluation criteria of the residential environment, and through relative literature documenting plans for the adjustment of urban and housing environments. In terms of the methodological approach, decisions were made based on the results of an expert focus-group-interview, a goodness-of-fit test, and by using the analytic network decision-making method from which the correlation among items can be considered. Results of this analysis show that the, order of importance of factors for a community-based residential environment is as follows: interactional character, cognitive character, and locational character. Furthermore, the most important aspect for each of these factors are the neighbor-hood relationship in terms of the interactional character, common consciousness for the cognitive character and place for locational character. The results of this study can be used by linking them with questionnaire items for basic resident research when a residential environment improvement project or a plan for the adjustment of urban and housing environments is planned.

• Nuclear Engineering and Technology
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• v.37 no.6
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• pp.511-524
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• 2005

Thermalhydraulic reactor simulation of tomorrow will require a new generation of codes combining at least three scales, the CFD scale in open medium, the component scale and the system scale. DNS will be used as a support for modelling more macroscopic models. NEPTUNE is such a new generation multi-scale platform developed jointly by CEA-DEN and EDF-R&D and also supported by IRSN and FRAMATOME-ANP. The major steps towards the next generation lie in new physical models and improved numerical methods. This paper presents the advances obtained so far in physical modelling for each scale. Macroscopic models of system and component scales include multi-field modelling, transport of interfacial area, and turbulence modelling. Two-phase CFD or CMFD was first applied to boiling bubbly flow for departure from nucleate boiling investigations and to stratified flow for pressurised thermal shock investigations. The main challenges of the project are presented, some selected results are shown for each scale, and the perspectives for future are also drawn. Direct Numerical Simulation tools with Interface Tracking Techniques are also developed for even smaller scale investigations leading to a better understanding of basic physical processes and allowing the development of closure relations for macroscopic and CFD models.

• Journal of Information Technology Services
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• v.14 no.3
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• pp.85-97
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• 2015

The information and communications construction business has the characteristics of an infrastructure industry and responsibility for the construction and maintenance of all ICT infrastructures. With the recent proliferation of the smart convergence of various industries based on ICT infrastructure, the role of the information and communications construction business has been highlighted to accommodate the convergence and implementation environment in construction and medical industries. Therefore, this paper seeks policy measures to establish the new role of the information and communications business under the rapidly developing smart convergence environment and the priorities of policy measures to strengthen the capability of the information and communications business using a quantitative model. The analysis result suggests that the difference in importance of each policy measure should be considered in order to execute effectively the policy of promoting the information and communications construction business. Given the constraint of limited budget, policy priorities include the development of new markets, and establishment of incentive for new technology. This study is significant for its theoretical contribution, being the first quantitative approach to policy priorities for the promotion of information and communications construction business under the smart convertgence environment.

• The Korean Journal of Physiology
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• v.24 no.2
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• pp.261-268
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• 1990

It has long been suggested that the cardiac atrium is a low pressure volume receptor controlling body fluid volume and blood pressure. Recently, the cardiac atrium has been found to contain a family of powerful peptides. To clarify the relationship between high blood pressure and the biologically active atrial peptides, experiments were done to define the characteristics of atrial natriuretic peptide secretion in the isolated perfused atria of renal hypertensive rats. Higher concentrations of plasma atrial natriuretic peptide and renin activity were observed in the two-kidney, one clip hypertensive rat compared to the normotensive rat. Atrial volume changes in response to pressure elevations were attenuated in hypertensive rats compared to normotensive rats. Incremental response to atrial volume changes in ANP secretion was accentuated in hypertensive rats. These date suggest that the accentuated atrial natriuretic peptide response to volume changes of hypertensive rats may be a physiological or pathphysiological adaptation to the high blood pressure and may be, at least in part, responsible for the elevated levels of plasma atrial natriuretic peptide observed in hypertensive rats.