• 한국콘텐츠학회논문지
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• 제3권3호
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• pp.85-97
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• 2003

MRI, CT, MRI, PET, SPECT, fMRI 등과 같은 단층의료영상은 병원에서 환자의 진단 및 치료 임상적 연구에서 폭넓게 사용되고 있다. 동일한 대상에 대하여 서로 다른 정보를 얻거나 비교를 하기 위하여 서로 다른 영상양식으로 촬영하거나 시간적 간격을 두고 단층영상을 획득하는 경우가 많다. 3차원 영상정합은 비교하고자 하는 두 영상을 하나의 3차원 좌표 공간으로 지도화하는 것이며, 크게 마커기반 정합과 특징기반 정합으로 분류된다. 뇌 영상의 3차원 정합은 뇌 수술부위 선정, 뇌 기능 연구, 뇌 지도화 연구 등에서 시각적 분석과 정량적 분석에서 중요한 위치를 차지한다. 본 논문에서는 뇌의 단층영상에 대하여 흔히 사용되고 있는 3차원 정합인 마커기반 정합법과 특징기반 정합법에 대하여 소개하고 이에 대한 비교 고찰을 행하고자 한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제19권1호
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• pp.13-18
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• 2008

Objectives : Internet addiction or pathologic internet use is one of the major mental health problems in children and adolescents in Korea. Internet addiction is defined as uncontrollable, markedly time-consuming internet use, which lasts for a period of at least six months. Internet addiction results in poor academic performance and negative parent-child relationships. By using $^{18}F$-fluorodeoxyglucose-positron emission tomography (FDG-PET), we investigated the effects of internet addiction on functional changes occurring in the adolescent brain. Methods : Adolescent patients with an internet addiction (4 boys and 2 girls; $15.6{\pm}1.2$ years) participated in this study. Eight healthy young adults (5 males and 3 females; 18-30 years old) with no previous history of psychiatric illness also participated as normal controls. Brain FDG-PET data was obtained with the participants in the resting condition and with no addictive stimuli. Results : Statistic parametric mapping analysis of the brain FDG-PET data revealed hypometabolic changes in the visual information processing circuits and hypermetabolic changes in the prefrontal areas in the adolescents with internet addiction, as compared with normal controls (p<.001). Conclusion : These results suggest a neuronal adaptation to excessive visual stimulation and synaptic plasticity due to internet addiction.

• 대한안전경영과학회지
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• 제1권1호
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• pp.197-206
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• 1999

Mind mapping is an efficient thinking skill which utilizes the whole left-right brain. The several studies which examine the effects of the mind map activities on the school education attain the desirable enhancement of the students' schoolwork achievement ＆ learning attitude. We now propose the utilization of the mind map activities at the safety education in order to decrease the students' accidents in school and to enhance the awareness of safety.

• 한국산학기술학회논문지
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• 제22권3호
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• pp.536-545
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• 2021

본 연구는 전기향로를 이용한 침향 흡입이 스트레스와 뇌파에 미치는 영향을 파악하기 위해 시행되었다. 'H' 발달센터 공고로 모집한 성인 남녀 16명 대상으로 2019년도 09월부터 2020년 4월까지 실시하였다. 전기향로에 침향편(沈香片)을 올려놓고 침향 흡입 전과 후의 스트레스 반응과 뇌파 측정을 비교 분석하여 침향 흡입이 스트레스 대처자원의 가능성을 알아보고자 하는 것이다. 뇌파 측정은 19 Channel, Brainmaster Discovery로 하였으며, 분석은 NeuroGuide와 LORETA를 사용하였다. 수집된 자료는 SPSS/WIN 21.0 프로그램으로 기술 통계, Wilcoxon 부호 순위 검정을 하였다. 결과는 첫째, 침향 흡입 후 스트레스 반응 지수는 분노, 우울, 신체화 모든 항목에서 유의수준 0.01로 유의미한 차이로 감소하였다. 둘째, 침향 흡입 후 뇌파에서 측정 부위 19곳 중에서 FP1 1곳을 제외한 18곳에서 Alpha Wave가 증가하였고, 유의수준 0.05에서 확인되었다. 감정에 영향을 주는 영역(우측 측두엽, T6)에서 침향 흡입 전과 후의 차이가 가장 크게 나타났다. 셋째, LORETA 분석 결과 침향 흡입 후 기억과 정서적 활동에 중요한 뇌 영역(BA40)에서 Alpha Wave가 증가하였다. 이러한 결과로 전기향로를 이용한 침향 흡입이 스트레스와 뇌파에 긍정적인 영향을 미쳐 스트레스 대처 자원이 될 가능성을 확인하였다.

• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1996년도 추계학술대회논문집
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• pp.66-71
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• 1996

This study is to observe human observe human positive and negative sensibility according to modalities such as auditory, visual, olfactory and tactile sense. Twenty university students are participated in this study. Experiment is performed in the subject room specially designed. Measurement system is Spectrum 32 (Cadwell) and is capable of brain mapping. The results shows brain local areas showing statistically significant difference between the positive and negative sensibility in ergonomics.

• 한국초등과학교육학회지:초등과학교육
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• 제26권1호
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• pp.49-62
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• 2007

The higher cognitive functions of the human brain including teaming are hypothesized to be selectively distributed across large-scale neural networks interconnected to the cortical and subcortical areas. Recently, advances in functional imaging have made it possible to visualize the brain areas activated by certain cognitive activities in vivo. Neural substrates for teaming and motivation have also begun to be revealed. Functional magnetic resonance imaging (fMRI) provides a non-invasive indirect mapping of cerebral activity, based on the blood- oxygen level dependent (BOLD) contrast which is based on the localized hemodynamic changes following neural activities in certain areas of the brain. The fMRI method is now becoming an essential tool used to define the neuro-functional mechanisms of higher brain functions such as memory, language, attention, learning, plasticity and emotion. Further research in the field of education will accelerate the verification of the effects on loaming or help in the selection of model teaching strategies. Thus, the purpose of this study was to review brain study methods using fMRI in science education. In conclusion, a number of possible strategies using fMRI for the study of elementary science education were suggested.

• Journal of Korean Neurosurgical Society
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• 제61권3호
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• pp.402-406
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• 2018

In contrast to many of the malignant tumors that occur in the central nervous system in adults, the management, responses to therapy, and future perspectives of children with malignant lesions of the brain hold considerable promise. Within the past 5 years, remarkable progress has been made with our understanding of the basic biology of the molecular genetics of several pediatric malignant brain tumors including medulloblastoma, ependymoma, atypical teratoid rhabdoid tumour, and high grade glioma/diffuse intrinsic pontine glioma. The recent literature in pediatric neuro-oncology was reviewed, and a summary of the major findings are presented. Meaningful sub-classifications of these tumors have arisen, placing children into discrete categories of disease with requirements for targeted therapy. While the mainstay of therapy these past 30 years has been a combination of central nervous system irradiation and conventional chemotherapy, now with the advent of high resolution genetic mapping, targeted therapies have emerged, and less emphasis is being placed on craniospinal irradiation. In this article, the present and future perspective of pediatric brain malignancy are reviewed in detail. The progress that has been made offers significant hope for the future for patients with these tumours.

• Nuclear Medicine and Molecular Imaging
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• 제42권sup1호
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• pp.1-5
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• 2008

Primary brain tumor accounts for 1.4% of entire cancer. For males between the ages of 15 and 34 years, central nervous system tumors account for the leading cause of cancer death. $^{18}F-FDG$ PET has been reported that it can provide important diagnostic information relating to tumor grading and differentiation from non- tumorous condition. In addition, the degree of FDG metabolism carries prognostic significance. By mapping the metabolic pattern of heterogeneous tumors, $^{18}F-FDG$ PET can aid in targeting for stereotactic biopsy by selecting the subregions within the tumor that are most hypermetabolic and potentially have the highest grade. According to clinical research data, FOG PET is expected to be a helpful diagnostic tool in the management of brain tumors.

• Genomics & Informatics
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• 제13권2호
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• pp.40-44
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• 2015

DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcription. To understand how these two processes are genetically regulated and associated with each other, we examined the changes of chromatin accessibility and gene expression in response to genetic variation by means of quantitative trait loci mapping. Regulatory patterns commonly observed in yeast and human across different technical platforms and experimental designs suggest a higher genetic complexity of transcription regulation in contrast to a more robust genetic architecture of chromatin regulation.

• 대한핵의학회지
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• 제37권1호
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• pp.63-72
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• 2003

Functional MRI (fMRI) provides an indirect mapping of cerebral activity, based on the detection of the local blood flow and oxygenation changes following neuronal activity (Blood Oxygenation Level Dependent). fMRI allows us to study noninvasively the normal and pathological aspects of functional cortical organization. Each fMRI study compares two different states of activity. Echo-Planar Imaging is the technique that makes it possible to study the whole brain at a rapid pace. Activation maps are calculated from a statistical analysis of the local signal changes. fMRI is now becoming an essential tool in the neurofunctional evaluation of normal volunteers and many neurological patients as well as the reference method to image normal or pathologic functional brain organization.