Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)

The Polymer Society of Korea (한국고분자학회)
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Peripheral Nerve Regeneration by Asymmetrically Porous PLGA/Pluronic F127 Nerve Guide Conduit

  • Oh, Se-Heang (Dept. of Advanced Materials, Hannam Univ.) ;
  • Kim, Jun-Ho (Dept. of Advanced Materials, Hannam Univ.) ;
  • Song, Kyu-Sang (Dept. of Pathology, Chungnam Nat'l Univ. Hospital) ;
  • Jeon, Byeong-Hwa (Dept. of Physiology, Chungnam Nat'l Univ. Hospital) ;
  • Lee, Il-Woo (Dept. of Neurosurgery, Catholic Univ. Hospital) ;
  • Lee, Jin-Ho (Dept. of Advanced Materials, Hannam Univ.)
  • Published : 2006.10.13
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Abstract

We developed a novel method to fabricate a nerve guide conduit (NGC) with the porosity of submicron pore sizes (to prevent fibrous tissue infiltration) and hydrophilicity (for effective oxygen and nutrient permeation) using poly(lactic-co-glycolic acid) (PLGA) and Pluronic F127 by a modified immersion precipitation method designed by our laboratory. It was recognized that the hydrophilized PLGA/F127 (3 wt%) tube can be a good candidate as a NGC from the analyses of its morphology, mechanical strength, hydrophilicity, model nutrient permeability and in vivo nerve regeneration behavior using a rat model.

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