Journal of Pharmaceutical Investigation
- Volume 4 Issue 1_2
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- Pages.13-18
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- 1974
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Interaction of Beta-cyclodextrin with Some Pharmaceuticals
Beta-cyclodextrin과 의약품(醫藥品)과의 상호작용(相互作用)
- Kim, Shin-Keun (College of Pharmacy, Seoul National University)
- 김신근 (서울대학교 약학대학)
- Published : 1974.03.20
Abstract
Data are present for the interaction of beta-cyclodextrin with 7 pharmaceuticals in aqueous solution. By means of the solubility method of analysis, definite interaction were found to occur with all the compounds tested. The amount of these pharmaceuticals in equilibrium with their respective solid phase increased progressively with beta-cyclodextrin. A concentration of 1.5 g of beta-cyclodextrin per 100 ml of water increased the solubility of most compounds tested (except one) by 15-120%. Hydrolysis in alkali solution of chrolothiazide was retarded in the presence of beta-cyclodextrin.
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