The Biopharmaceutical Studies on the Some Compunding Drugs( III ) -Antipyritic Analgesic Effect on the Aminopyrine Combined with Atropine Sulfate by Writhing Method-

배합약물(配合藥物)의 생물약제학적(生物藥劑學的) 연구(硏究) ( III ) -Aminopyrine의 해열진통작용(解熱鎭通作用)에 미치는 Atropine Sulfate의 배합효과(配合效果)

The comparative studies were made on the analgesic antipyretic effects of aminopyrine used individually and combined with parasympathetic agents (atropine sulfate). The analgesic antipyretic effects were eximined by Writhing's method to the experimental groups(mouse), and the following effects were found : 1) The active intensity of aminopyrine by it's oral administration combined with atropine sulfate is as follows. Amiinopyrine 80 mg/kg combided with Atropine sulfate 0.005 mg/kg=Aminopyrine 100 mg/kg 2) The most active range of intensity of Atropine sulfate(adjuvant) by it's oral administration is as follows. Atropine sulfate $0.004{\sim}0.005\;mg/kg$.