Archives of Pharmacal Research
- 제12권2호
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- Pages.138-142
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- 1989
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Structure of Purine Derivatives as Antitumor Effects
- Moharram, H.H. (National Organisation for Drug Control and Research) ;
- El-Bayouki, Khairy A.M. (National Research Center, Cairo, and Cancer Institute, Cairo University) ;
- Haggag, B. (National Research Center, Cairo, and Cancer Institute, Cairo University) ;
- Basyouni, W.M. (National Research Center, Cairo, and Cancer Institute, Cairo University) ;
- Osman, A.M. (National Organisation for Drug Control and Research)
- 발행 : 1989.06.01
초록
The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.