Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Anti-Tumor Effect of Cyclophosphamide, TUbercin-3 , and Picibanil on Sarcoma-180 Bearing Mice

Sarcoma-180 유발 생쥐에 대한 Cyclophosphamide, Picibanil 및 Tubercin-3의 투여효과

  • Lee, In-Seon (Dept. of Food Science and Technology, Keimyung University) ;
  • Kim, Hyuk-Il (Dept. of Food Science and Technology, Keimyung University) ;
  • Whang, Key (Dept. of Food Science and Technology, Keimyung University)
  • 이인선 (계명대학교 식품가공학과) ;
  • 김혁일 (계명대학교 식품가공학과) ;
  • 황기 (계명대학교 식품가공학과)
  • Published : 1994.12.01
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Abstract

This study was carried out to detemrine the efficacy of combined treatment of cyclophosphamide with tubericin-3 and or picibanil. One hundred sixty sarcoma-180 bearing mice were divided eight groups. Each group received saline, tubercin-3, picibanil , and cyclophosphamide along and/or received cyclophosphamide with tubercin-3 , with picibanil or with both tubercin-3 and picinanil, respectively.Average surviving time of each group of animals was as follows ; control was 10.9days, tubercin-3 was 15.1 days. picibanil was 12.6 days, and cylophosphamide was 17.9 days, In combined therapyy that cylophosphamide injected with tubercin-3 , the surviving time was 26.8 days an din the case of other therapy that cyclophosphamide injected with tubercin-3, the surviving time was 26.8 days an din the case of other therapy that cyclophosphamide injected with picibanil, the surviving time was 21.9 day and cyclophosphamide treated with both turbercin03 and picibanil, the surviving time was found to be 18.2 days, conclusively , the therapeutic potentiation seemed to be extended when combined tretment of the chemotherapeutics cyclophosphamide with either one of immunotherapeutics tubericin-3 or picibanil was tried, Combinatin of tubercin-3 and picibanil showed to be atagonistic each other. Yield of ascites fluid were determined 7 days after injectino of sarcoma-180 ascites tumor cells. Adminitration of cyclophosphamide, tubercin-3 , and picibanil alone and their various combinations reduced the yield of ascites fluid except for picibanil group.

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