Korean Journal of Food Science and Technology (한국식품과학회지)
- Volume 27 Issue 4
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- Pages.445-448
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- 1995
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- 0367-6293(pISSN)
Cytotoxic Effect of the Extract from Acetobacter aceti OLS-001
초산균체 추출물의 In Vitro계 암세포 증식 억제 효과
- Lee, Byung-Woo (Ottogi Research Center) ;
- Yoo, Yik-Je (Ottogi Research Center) ;
- Yoo, Moo-Yung (Ottogi Research Center) ;
- Hwang, Woo-Ik (College of Medicine, Korea University) ;
- Choi, Chun-Un (Ottogi Research Center)
- Published : 1995.08.31
Abstract
This study was performed to observe cytotoxic effect of Acetobacter aceti OLS-001 extract against cancer cell lines, including mouse leukemic lymphocyte(P388, L1210) and human rectal(HRT-18) cell. The anticancer substance were prepared by ethanol precipitation of the glass bead extraction combined with hot water of Acetobacter aceti OLS-001. The growth rates of the cancer cells in medium containing Acetobacter aceti extract were inhibited gradually to a significant degree in proportion to the increase of the extract concentration. Morphology of HRT-18 cells in medium containing Acetobacter aceti extract were seen to be shrinked and fragmented.
Acetobacter aceti OLS-001 균체에서 추출한 추출물의 농도가 높을수록, 배양시간이 길수록 암세포의 증식 억제 효과가 높게 나타났으며, 현미경 관찰에서 본래의 암세포 형태가 변형되고 세포막사이의 경계막이 흐트러지면서 사멸하는 현상을 나타냈다.