Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
권호 표지

Effect of Acute Pretreatment of Ethanol on the Liver Damage in Toluene Treated Rats

흰쥐에 Toluene과 Alcohol의 병행투여가 간 손상에 미치는 영향

  • 전재현 (계명대학교 자연과학대학 공중보건학과) ;
  • 임영숙 (대구공업전문대학 식품영양과) ;
  • 윤종국 (계명대학교 자연과학대학 공 중보건학과)
  • Published : 1996.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

To evaluate an effect of acute ethanol pretreatment on the liver injury in toluene-treated rats, toluene(50% in olive oil) was intraperitoneally given four times at 0.3ml/100g body weight at interval of one day to the ethanol-pretreated rats(0.3ml of 50%/100g body weight). The increasing rate of liver weitht per body weight(%), serum levels of alanine aminotransferase (ALT) activity, liver lipid peroxide content was higher in toluene treated rats pretreated with ehtanol than those treated with toluene alone. Concomitantly the hepatic glucose-6-phosphatase activity was increased whereas glutathione content was decreased by ehtanol pretreatment before toluene administration in rats. In case of direct administration of acetaldhyde or benzaldehyde to the rats, the liver weitht per body weight(%) and serum levels of ALT activity were almost higher than the control group. There results indicate that the toluene treated rats showed the reversible injury of liver and intensified. however, by the ethanol treatment.

Keywords

References

  1. N. Engl. J. Med. v.268 Toluene habituation Satran,R.;Dodson,V.
  2. N. Eng. J. Med. v.275 Permanent encephalopathy from toluene inhalation Knox,J.W.;Nelson,J.R.
  3. Ann. Neurol. v.2 Persistent cerebellar ataxia after exposure to toluene Boor,J.W.;Hurtig,H.I.
  4. Toxicol. Appl. Pharmacol. v.88 Discriminative stimulus properties of toluene in the mouse Rees,D.C.;Knisely,J.S.;Jordan,S.
  5. Science v.170 Glue sniffing causes heart block in mice Taylor,G.J.;Harris,W.S.
  6. Ann. Inter. Med. v.103 Toluene sniffing and severe sinus bradycardia Zee-Cheng,C.S.;Mueller,C.E.;Gibbs,H.R.
  7. Clin. Toxicol. v.11 Toxicology of toluene (methylbenzene): Review of current literature Hayden,J.W.;Peterson,R.G.;Bruckner,J.V.
  8. J. Occup. Med. v.31 no.12 Toluene and hepatotoxicity Morris,R.J.
  9. J. Work Environ. Health. v.6 Biotransformation of organic solvents. A review Scand Toftgard,R.;Gustafsson,J.A.
  10. "Toluene" in Medical Toxicology Ellenhorn,M.J.;Barceloux,D.G.
  11. J. Pharmacol. Exp. Ther. v.183 Relationship of alcohol metabolism to the potentiation of CCl₁hepatotoxicity induced by aliphatic alcohols Traiger,G.J.;Plaa,G.L.
  12. Biochem. Pharmacol. v.29 Interactions between ethanol and other hepatotoxic agents Strubelts,O.
  13. 한국독성학회지 v.11 no.2 흰쥐에 있어서 주정중독이 bromobenzene 대사에 미치는 영향 김중우;신중규;윤종국
  14. Science. v.162 Hepatic microsomal enzymes in man and rats: induction and inhibition by ethanol. Rubin,E.;Lieber,C.S.
  15. Toxicol. Appl. Pharmacol. v.67 no.2 Effect of chronic ethanol administration in bromobenzene liver toxicity in the rat Hetu,C.;Dumont,A.;Joly,J.G.
  16. Biochem. Phamacol. v.24 Elevation in blood acetaldehyde by pargyline during ethanol administration Cohen.G.;MacNamee,D.;Debiec,D.
  17. Toxicol. Appl. Phamacol. v.82 no.2 A comparative study of the effects of benzene. toluene and xylene on their in vitro metabolism and drug-metabolizing enzymes in rat liver. Pathiratne,A.;Puyear,R.L.;Brammer,U.D.
  18. Gastroenterology v.66 Increased CCl₄hepatotoxicity and its metabolism after chronic ethanol consumption Hasushi,Y.;Tescke,R.;Lieber,C.S.
  19. Am. J. Clin. Pathol. v.28 A colormetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase Reitman,S.;Frankel,S.
  20. J. Clin. Invest. v.34 A note on the spectrophoto metric assay of glutamic oxalo acetic transaminase in human blood serum Karmen,A.
  21. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa,H.;Ohish,N.;Yaki,K.
  22. Arch. Biochem. Biophys. v.82 Tissue sulfhydryl group. Ellman,G.L.
  23. J. Biol. Chem. v.193 Protein measurement with the folin phenol reagent Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.
  24. Statistics for the Biological Sciences (2.ed.) Schefler,W.C.
  25. Cellular injury and cellular death " in Robbins Pathologic basis of disease"(5th ed.) Cotran,R.S.;Kumar,V.;Robbins,S.L.;Schoen,F.J.
  26. Gastroenterology v.66 Increased CCl₄hepatotoxicity and its mechanism after chronic ethanol consumption Hasushi,Y.;Teschke,R.;Lieber,C.S.
  27. Aldehyde oxidizing enzymes, Enzymatic Basis of Detoxication. v.1 Weiner,H.;Jakoby,W.B.(ed.)