The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

The neuroprotective effect of Acori graminei rhizoma extract against cerebral ischemia in rats

석창포(石菖蒲)가 뇌허혈(腦虛血)을 유발(誘發)시킨 백서(白鼠)에서의 뇌신경보호효과(腦神經保護效果)

  • Keum, Hyeon-Su (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Jeon, Yeon-Yi (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Lee, Eun-Ju (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Park, Chi-Sang (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Park, Chang-Gook (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Heo, Jin-Hwa (Department of Pharmacology, College of Oriental Medicine, Kyungsan University) ;
  • Yang, Chae-Ha (Department of Pharmacology, College of Oriental Medicine, Kyungsan University) ;
  • Cho, Jung-Sook (Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Kang, Seoung-Jun (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyungsan University)
  • 금현수 (경산대학교 한의과대학 심계내과학교실) ;
  • 전연이 (경산대학교 한의과대학 심계내과학교실) ;
  • 이은주 (경산대학교 한의과대학 심계내과학교실) ;
  • 박치상 (경산대학교 한의과대학 심계내과학교실) ;
  • 박창국 (경산대학교 한의과대학 심계내과학교실) ;
  • 허진화 (경산대학교 한의과대학 약리학교실) ;
  • 양재하 (경산대학교 한의과대학 약리학교실) ;
  • 조정숙 (동국대학교 의과대학 약리학교실) ;
  • 강승준 (경산대학교 한의과대학 심계내과학교실)
  • Published : 2001.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Object: Acori graminei rhizoma(AGR) extract is clinically used to treat the cerebral ischemia in Korea. The present study was undertaken to study the neuroprotective effect of AGR extract in middle cerebral artery occlusion(MCAO) rats. Methods: Changes of extracellular levels of glutamate, aspartate, GABA, glycine, taurine, tyrosine, alanine in striatum were collected at 20 minutes interval by in vivo microdialysis and then analyzed by HPLC(high performance liquid chromatography) in rats subjected to permanent focal cerebral ischemia induced by 2 hours of MCAO. AGR extract was orally administrated before MCAO. Different animals were used for measurement of cerebral infarction volume induced by 24 hours of MCAO with TTC staining and image analysis. Result : The infarction volume was decreased and focal cerebral ischemia - induced increase of extracellular glutamate, aspartate, and tyrosine were inhibited after the treatment of AGR extract. On the other hand, the increase of glycine and alanine not but GABA and taurine were enhenced after the treatment of AGR extract. Conclusion: These results suggest that AGR extract can playa role in protecting against cerebral ischemia by regulating extracellular levels of excitatory and inhibitory amino acid neurotransmitters.

Keywords

References

  1. 신경학원론 서울대학교의과대학(編)
  2. HARRISON'S 내과학 Kurt J. Isselbacher
  3. 약물료법 v.2 의학교육연수원
  4. 전국한의과대학심계내과학교실(編)
  5. 중의림상대전 양사주;장수생;부경화
  6. 대한한의학회지 v.21 no.1 우황청심환이 뇌허혈을 유발시킨 흰쥐의 신경전달물질에 미치는 영향 박치상;이은주;박원미;김미려;조정숙;김영호(등)
  7. 대한한방내과학회지 v.21 no.1 성향정기산이 뇌허혈을 유발시킨 백서의 신경전달물질에 미치는 영향 예경욱;박치상;이은주;송지혜;김미려;조정숙(등)
  8. 신농본초경 오보
  9. 본초강목 이시진
  10. 증보본초비요 v.3 왕인암
  11. 본초학 전국한의과대학본초학교수(공동편저)
  12. 임상배합본초학 강병수;김영판
  13. J Cereb Blood Flow Metab v.9 Dynamics of extracellular metabolites in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis Hillered, L.;Hallstrom, A.;Segersvard, S.;Persson, L.;Ungerstedt, U.
  14. J. Cereb. Blood flow Metab. v.15 In vivo models of cerebral ischemia : Effects of parenterally administered NMDA receptor glycine site antognoists Warner, D.S.;Martin, H.;Ludwig, P.;McAllister, A.;Keana, J.F.W.;Weber, E.
  15. Acta. Phys. Scand. v.128 Microdialysis in the study of extracellular levels of amino acids in the rat brain Tossman, U.;Ungerstedt, U.
  16. J Neurochem. v.49 Extracellular adnosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia Hagberg, H.;Andersson, P.;Lacarewicz, J.;Jacobson, I.;Butcher, S.;Sandberg, M.
  17. Stroke v.20 Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion Nagasawa, H.;Kogure, K.
  18. Bioststisstics v.3 A foundation for analysis in the health science Dinal, W.W.
  19. 하간삼육서 유완소
  20. 동원십종의서 이고
  21. 역석단계의론 주진형
  22. 편주의학입문 이천
  23. 임증지남의안 엽천사
  24. 의림개착 왕청임
  25. 실용중의심혈관병학 굴송백;이가경
  26. 임상중풍학 김영석
  27. Stroke v.24 a glutamate release inhibitor, protects against focal cerebral ischemic damage Leach, M.J.;Swan, J.H.;Eisenthal, D.;Dopson, M.;Nobbs, M.
  28. 아담스신경과학 Raymond D. Adams;Maurice Victor;Allan H. Ropper
  29. Neurosci. Lett. v.58 Glutamate neurotoxicity in cortical cell culture is calcium dependent Choi, D.W.
  30. 신경전달물질 v.2 서유헌
  31. 신경전달물질 기초와 임상 v.1 허인회;안형수;강봉수;권광일;권래성;김진
  32. J. Neurochem. v.58 Excitatory transmitter amino acid release from the ischemic rat cerebral cortex Simpson, R.E.;O'regan, M.H.;Perkins, L.M.;Phillis, J.W.
  33. 신경전달물질과 약물 Zygmunt L. Kruk;Christopher J. Pycock
  34. Anesth Analg. v.84 no.5 Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerrebral ischemia by local nitric oxide synthase inhibition Kahn, R.A.;Pananh, M.;Kiffel, S.;Weinberger, J.
  35. J Neurotrauma v.12 no.3 The effect of the glycine site-specific NMDA antagonist ACEA1021 on ischemic brain damage caused by acute subdural hematoma in the rat Tsuchida, E.;Bullock, R.
  36. J Cereb Blood Flow Metab. v.15 no.5 Blood-brain barrier taurine transport during osmotic stress and in focal cerebral ischemia Stummer, W.;Betz, A.L.;Shakui, P.;Keep, R.F.
  37. Am J Physiol. v.240 no.2 Effect of taurine on calcium paradox and ischemic heart failure Kramer, J.H.;Chovan, J.P.;Schaffer, S.W.
  38. J Cereb Blood Flow Metab. v.19 no.7 Kynurenine hydroxylase inhibitors reduce ischemic brain damage Cozzi, A.;Carpenedo, R.;Moroni, F.
  39. J Cereb Blood Flow Metab. v.13 no.3 Inhibition of tyrosine phosphorylation prevents delayed neuronal dealth folliwing cerebral ischemia Kindy, M.S.
  40. 신경병리학 지제근