The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

The Steroid Sparing Effects of Cheongsangboha-tang in Asthmatic Patients

청상보하탕(淸上補下湯)의 기관지천식환자에 대한 스테로이드 절약효과

  • Choi Jun-Yong (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee Jae-Sung (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Ju Chang-Yeop (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Jung Hee-Jae (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Rhee Hyung-Koo (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Jung Sung-Ki (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Hwang Woo-Suck (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 최준용 (경희대학교 한의과대학 폐계내과학교실) ;
  • 이재성 (경희대학교 한의과대학 폐계내과학교실) ;
  • 주창엽 (경희대학교 한의과대학 폐계내과학교실) ;
  • 정희재 (경희대학교 한의과대학 폐계내과학교실) ;
  • 이형구 (경희대학교 한의과대학 폐계내과학교실) ;
  • 정승기 (경희대학교 한의과대학 폐계내과학교실) ;
  • 황우석 (경희대학교 한의과대학 폐계내과학교실)
  • Published : 2003.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

Background : In recent years, the glucocorticoid hormone has become a fundamental medication for asthma. However, a long period of hormone administration will result. in general. side effects on many body parts as well as hormone dependence, which has become a serious problem for western physicians. Objectives : We aimed to identify the clinical effects of Cheongsanghoha-tang and the steroid sparing effects of Cheongsanghoha-tang on. Materials and Methods : A subject group consists of 36 asthmatics who had been treated with Cheongsanghoha-tang for four weeks. Cheongsanghoha-tang is a herbal decoction, which has been used of the traditional therapeutic agent of asthma. PFT, QLQAKA, blood eosinophil, serum IgE, Serum IL-4. IL-5, IFN-${\gamma}$ were checked before and 4weeks after the treatment. Results : The only FVC% in ICSG among asthmatic patients was increased significantly compared to NICSG. Treatment of Cheongsanghoha-tang for four weeks resulted in significant increase in QLQAKA. The NICSG treated with Cheongsangboha-tang for four weeks were no significant difference in the blood eosinophil, serum IgE, IL-4 and IL-5. The PFT and QLQAKA in NICSG were increased significantly after 4 weeks treatment. But the serum IFN-${\gamma}$ in NICSG was decreased significantly after 4 weeks treatment. Discontinuation of treatment with inhaled corticosteroid in ICSG resulted in insignificant changes in PFT, the blood eosinophil, the serum IgE, IL-4, IL-5 and IFN-${\gamma}$ and significant increase in QLQAKA. As a result. 8 of 13 cases were cured with hormones completely and the rest of ICSG reduced the dose of ICS. Conclusions : This study shows that Cheongsanghoha-tang has the effects on the improvement of pulmonary function and cures asthmatic patients. These findings demonstrate that Cheongsanghoha-tang has the steroid sparing effect. Some satisfactory therapeutic results have been obtained in treating hormone-dependent asthma by Cheongsanghoha-tang. However. the concept and mechanism of hormone-dependent asthma have not been fully defined yet, and the standard for judging therapeutic effects have not been established. Obviously further researches concerning all these are still necessary.

Keywords