Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Effects of Guemengja (Rosae Laevigatae Michx.) Extracts on Serum Lipid Composition and Antioxidative Capacity in Rats Fed High Oxidized Fat

금앵자(金櫻子) 추출물이 과산화지질을 급여한 흰쥐의 혈청지질구성과 할산화능에 미치는 영향

  • Published : 2004.10.01
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Abstract

Effects of Guemengja (Rosae Laevigatae Michx.) Extracts on serum and liver lipid composition and antioxidative capacity were investigated in rat fed high oxidized fat. Twenty eight male Sprague-Dawley rats weighing 159.35$\pm$2.17g were blocked into four groups according to body weight and raised seven weeks with basal diet (normal group, I), basal diet and 10% oxidized fat (control group, II), basal diet, 10% oxidized fat and 100mg/kgg Guemengja Extracts (100mg/kg Guemengja Extracts group, III) and basal diet, 10% oxidized fat and 200mg/kg Guemengja Extracts (200mg/kg Guemengja Extracts group, IV). The level of plasma total cholesterol and triglyceride showed a tendency to decrease, whereas the plasma HDL-cholesterol concentration revealed a tendency to increase in guemengja extracts groups. The level of liver total cholesterol showed no significantly different in all treatment groups, however the level of liver triglyceride showed a tendance to decrease in guemengja extracts groups. Thiobarbituric acid(TBARS) values in plasma and liver showed a tendence to decrease in guemengja extracts groups. The guemengja extracts samples have also decreased the plasma GOT and GPT activities, whereas they have increased the liver glutathione peroxidase, superoxide dismutase and catalase activity.

금앵자 추출물이 과산화지 질을 급여한 횐 쥐의 혈장 및 간장지질구성과 항산화능에 미치는 영향을 검토했다 혈장 총 콜레스테롤 량은 과산화지질 첨가군 모두가 정상군보다 증가하였으나, 금앵자 추출물 첨가에 의해 하락하였다. 혈장HDL-cholesterol량은 금앵자 첨가군이 대조군 보다 높은 경향을 나타내었다. 혈장 중성지질량은 정상군과 금앵자 첨가군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다. 간장의 총 콜레스테롤 량은 전 처리군에서 유의한 차이를 나타내지 않았으며, 중성지질 량은 정상군과 금앵자 첨가군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다 혈장내 TBARS량은 정상군과 금앵자군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다. 간장내 TBARS량은 과산화지질 첨가에 의해 증가하였으나, 금앵자 첨가에 의해 하락했다. 혈장 GOT 및 GPT의 활성치는 관산화지질 첨가군에서 증가하였으나, 금앵자처리에 의해 하락했다(P＆lt;0.05). 간장 GSH-Px, SOD 및 CAT활성치는 금앵자처리에 의해 증가하는 경향을 보였다.

Keywords

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