Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Anticancer and Immuno - Activity of Onion Kimchi Methanol Extract

양파김치 메탄올추출물의 항암 및 면역활성

  • Park, Kyung-Uk (Dept. of Food and Nutrition, Sunchon National University) ;
  • Kim, Jae-Yong (Research Institute of Basic Science, Sunchon National University) ;
  • Cho, Young-Sook (Dept. of Food and Nutrition, Sunchon National University) ;
  • Lee, Sung-Tae (Dept. to Biology, Sunchon National University) ;
  • Jeong, Chang-Ho (Dept. of Applied Life Sciences, Graduate School, Gyeongsang National University) ;
  • Kang, Kap-Suk (Group Dept. of Leisure Industry, Pusan Information and Technology College) ;
  • Seo, Kwon-Il (Dept. of Food and Nutrition, Sunchon National University)
  • 박경욱 (순천대학교 식품영양학과) ;
  • 김재용 (순천대학교 기초과학연구소) ;
  • 조영숙 (순천대학교 식품영양학과) ;
  • 이성태 (순천대학교 생물학과) ;
  • 정창호 (경상대학교 응용생명과학부) ;
  • 강갑석 (부산정보대학 레저산업개발) ;
  • 서권일 (순천대학교 식품영양학과)
  • Published : 2004.11.01
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Abstract

Antitumor activities of onion methanol extract (OME) and onion Kimchi methanol extract (OKME) were investigated by using aflatoxin $B_1$-mediated Salmonella typhimurium mutagenicity and the model of cytotoxicity on the cancer cell lines. Their immune activities were also investigated by using mouse spleen cells and macrophage cell lines, respectively. OME and OKME showed the enhanced antimutagenicity in a dose-dependent manner in particular, the activity of OKME was higher than that of OME. OME and OKME decreased over 20% of the proliferation of the A549 (lung cancer cell) and MCF-7 (breast cancer cell) cell lines when compared with the control at 1,000 ${\mu}$g/mL. The proliferation of mouse spleen cells and the NO production in marcrophage cell lines treated OME and OKME were increased in a dose-dependent manner compared with untreated control cells, and their activities of OKME were higher than those of OME.

양파 및 양파김치에 대한 항암 및 면역활성을 조사한 결과는 다음과 같다. 양파 및 양파김치 메탄올 추출물은 aflatoxin $B_1$로 돌연변이를 유도한 Salmonella typhimurium에 대하여 농도 의존적으로 항돌연변이 효과가 큰 것으로 나타났으며, 양파김치 첨가군이 양파의 첨가군보다 그 효과가 더욱 크게 나타났다. 양파 및 양파김치 메탄올 추출물은 A549 및 MCF-7 암세포주에 처리한 결과 추출물을 처리하지 않은 대조구에 비하여 1,000 ${\mu}$g/mL 농도에서 모두 20% 이상 그 성장을 억제하였다. 양파김치 메탄올 추출물은 농도에 비례하여 비장세포의 증식을 유도하였고, 양파 추출물보다 더 높은 증식을 유도하였다. 양파 및 양파김치 메탄올 추출물을 처리한 대식세포주에서 NO의 생성이 농도 의존적으로 증가하였으며, 역시 양파김치 추출물이 양파 추출물보다 더 많은 NO을 생성량을 유도하였다.

Keywords

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