KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Selection of Oriental Medicinal Plants for Screening of Anticancer Agents

항암소재의 발굴을 위한 한방소재의 선별

  • Park, Keun-Hyoung (Department of Food and Biotechnology, and Center for Food Function and Safety, Hoseo University) ;
  • Kim, So-Young (Department of Food and Biotechnology, and Center for Food Function and Safety, Hoseo University) ;
  • Chae, Hee-Jeong (Department of Food and Biotechnology, and Center for Food Function and Safety, Hoseo University)
  • 박근형 (호서대학교 식품생물공학과 및 식품기능안전연구센터) ;
  • 김소영 (호서대학교 식품생물공학과 및 식품기능안전연구센터) ;
  • 채희정 (호서대학교 식품생물공학과 및 식품기능안전연구센터)
  • Published : 2007.06.30
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Abstract

An oriental medicinal database was used from medicinal plants for screening of anticancer agents. The prescription frequency and dosage of medicinal plats in 170 anticancer prescriptions were analyzed. From the total prescription score of each medical plant, it was found that high-scored medicinal plants have been widely studied in the previous research on the cancer treatment. Consequently, dangui, hwangui, banha, bachul, jinpy, insam, bacjakyak, deahwang, chungoong, jimo, chunnamsung, omija, hyunggae, huekchook, banggi, boclyung, osooyou were selected as raw materials for the screening of anticancer agents.

암에 효능을 보이는 생리활성소재의 탐색원을 발굴하기 위한 방법의 하나로 동양의학 데이터베이스의 처방정보를 활용하였다. 신동의약보감에 포함되어 있는 170건의 암 처방 천연약재의 처방빈도와 처방분량을 분석하였다. 처방순위와 처방 분량에 따라 마련된 점수표 (score table)를 기준으로 총처방점수 (total prescription score)를 작성하였다. 선행연구 결과들을 조사한 결과 총처방점수가 높은 약재들을 소재로 한 관련 보고들이 많은 것으로 나타났다. 결과적으로 당귀, 황기, 감초, 반하, 백출, 진피, 인삼, 백작약, 대황, 천궁, 지모, 천남성, 오미자, 형개, 흑축, 방기, 복령, 오수유 등이 암에 효과가 있으며 이들 약재를 이용한 항암 소재의 탐색이 제안되었다.

Keywords

References

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