Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antioxidant and Anti-diabetes Activity of Extracts from Machilus thunbergii S. et Z.

토후박 추출물의 항산화 및 항당뇨 활성

  • Xu, Ming Lu (Henan Institute of Science and Technology) ;
  • Hu, Jian He (Henan Institute of Science and Technology) ;
  • Wang, Lan (School of Biotechnology, Kangwon National University) ;
  • Kim, Hyun-Sam (School of Biotechnology, Kangwon National University) ;
  • Jin, Cheng-Wu (School of Biotechnology, Kangwon National University) ;
  • Cho, Dong-Ha (School of Biotechnology, Kangwon National University)
  • 허명록 (하남과학기술학원) ;
  • ;
  • 왕란 (강원대학교 BT특성화대학) ;
  • 김현삼 (강원대학교 BT특성화대학) ;
  • 김성무 (강원대학교 BT특성화대학) ;
  • 조동하 (강원대학교 BT특성화대학)
  • Received : 2009.12.23
  • Accepted : 2010.02.11
  • Published : 2010.02.28
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Abstract

Machilus thunbergii was an important medicinal resource and distributed widely in China. In this study, the bioactivities of dichloromethane fraction (DF) and water fraction (AF) from Machilus thunbergii methanol extract were investigated. Total phenolic contents of DF and AF were 57.90 mg Gal/g and 189.92 mg Gal/g, and total flavonoid contents were 17.34 mg Que/g and 58.38 mg Que/g respectively. The $EC_{50}$ for DPPH radical scavenging activity of DF and AF were $24.37\;{\mu}g/m{\ell}$ and $2.10\;{\mu}g/m{\ell}$. Reducing power and hydroxyl radical scavenging activities of AF were higher than those of DF. The $\alpha$-glucosidase inhibitory activity of AF ($IC_{50}\;=\;1.13\;{\mu}g/m{\ell}$) was higher than that of DF ($IC_{50}\;=\;5.34\;{\mu}g/m{\ell}$). The cell viability was showed that only the DF had anti-proliferation effect on human cancer cell HT-29. These results suggested that both the DF and AF extract of Machilus thunbergii were potential materials for anti-diabetes and functional food for their radical scavenging activity.

Keywords

References

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