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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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PER3, a novel target of miR-103, plays a suppressive role in colorectal cancer in vitro

  • Hong, Zhang (The Nurse Department of Organ Transplantation, Xiangya Hospital, Central South University) ;
  • Feng, Zhang (Xiangya School of Medicine, Central South University) ;
  • Sai, Zhang (Institute of Medical Sciences, Xiangya Hospital, Central South University) ;
  • Tao, Su (Institute of Medical Sciences, Xiangya Hospital, Central South University)
  • Received : 2013.10.01
  • Accepted : 2013.12.23
  • Published : 2014.09.30
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Abstract

Colorectal cancer has become the third most common cancer and leads to high mortality worldwide. Although colorectal cancer has been studied widely, the underlying molecular mechanism remains unclear. PER3 is related to tumor differentiation and the progression of colorectal cancer. High expression of miR-103 is associated with poor prognosis in patients with colorectal cancer. However, the relationship between miR-103 and PER3 in CRC cells remains unclear. In this study, we found that PER3 was downregulated in CRC tissues and CRC cell lines, whereas miR-103 was upregulated in CRC cell lines. We also found that PER3 promoted CRC cells apoptosis. These results indicate that PER3 plays a suppressive role in CRC cells. Moreover, we found that PER3 was targeted, at least partially, by miR-103. Taken together, we provide evidence to characterize the role of PER3 in CRC, which may be a new therapeutic target for CRC.

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References

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