Journal of Korean Dental Science

Korean Academy of Dental Science (대한치의학회)
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Study on Biocompatibility and Mineralization Potential of Capseal

  • Bae, Kwang Shik (Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Chang, Seok Woo (Department of Conservative Dentistry, School of Dentistry, Kyung Hee University) ;
  • Kum, Kee Yeon (Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Lee, Woo Cheol (Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
  • Received : 2014.04.06
  • Accepted : 2014.05.28
  • Published : 2014.06.30
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Abstract

Purpose: Capseal I and Capseal II are calcium silicate and calcium phosphate based experimental root canal sealers. This study sought to evaluate the biocompatibility and mineralization potential of Capseal I and Capseal II. Materials and Methods: The biocompatibility and mineralization related gene expression (alkaline phosphatase [ALP], bone sialoprotein [BSP], and osteocalcin) of Capseal I and Capseal II were compared using methylthiazol tetrazolium assay and reverse transcription-polymerization chain reaction analysis, respectively. The results were analyzed by Kruskal-Wallis test. A P-value of <0.05 was considered significant. Result: Both Capseal I and Capseal II were favorable in terms of biocompatibility, influencing the messenger RNA expression of ALP and BSP. Conclusion: Within the limitation of this study, Capseal is biocompatible, with mineralization promoting potential; thus, it could be a promising root canal sealer.

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