한국식품과학회지 (Korean Journal of Food Science and Technology)

한국식품과학회 (Korean Society of Food Science and Technology)
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Anti-inflammatory effect of Geranium thunbergii on lipopolysaccharide-stimulated RAW 264.7 cells

  • Kwon, Tae-Hyung (Chuncheon Bioindustry Foundation) ;
  • Lee, Su-Jin (Department of Herbal Medicine Resource, Kangwon National University) ;
  • Kim, You-Jeong (Food Science and Biotechnology Major, Andong National University) ;
  • Park, Jung-Ja (Department of Food and Biotechnology, Hankyong National University) ;
  • Kim, Taewan (Food Science and Biotechnology Major, Andong National University) ;
  • Park, Nyun-Ho (Gyeongbuk Institute for Marine Bio-Industry)
  • 투고 : 2016.07.05
  • 심사 : 2016.08.09
  • 발행 : 2016.12.31
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초록

Geranium thunbergii is a perennial plant commonly used as an oriental medicine for prevention of diarrhea, constipation, and gastrointestinal disorders. However, its anti-inflammatory effect has not been evaluated thus far. Therefore, the present study aimed to investigate the anti-inflammatory effect of G. thunbergii. In this study, G. thunbergii extracted with methanol; this methanol extract was further partitioned using various solvents, and G. thunbergii ethyl acetate fraction (GTEF) was obtained. To determine the anti-inflammatory activity of G. thunbergii, the effects of GTEF on nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264.7 cells were evaluated. GTEF suppressed NO production in a dose-dependent manner without any toxic effects. In addition, western blotting was performed to examine the effect of GTEF on expression of inducible nitric oxide synthase and cyclooxygenase-2. These results suggest that GTEF as a phytoextract may be useful for the prevention or treatment of inflammation.

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참고문헌

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