The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지
DOI QR코드

DOI QR Code

A review of traditional Korean medical treatment for cancer-related cognitive impairment

암 관련 인지 장애의 한의학적 치료에 대한 문헌 고찰

  • Lee, Hye-Yoon (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Jung-Eun (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Mikyung (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Joo-Hee (Clinical Research Division, Korea Institute of Oriental Medicine)
  • 이혜윤 (한국한의학연구원 임상연구부) ;
  • 김정은 (한국한의학연구원 임상연구부) ;
  • 김미경 (한국한의학연구원 임상연구부) ;
  • 김주희 (한국한의학연구원 임상연구부)
  • Received : 2016.08.22
  • Accepted : 2016.09.29
  • Published : 2016.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This article aims to review clinical studies related to traditional Korean medicine (TKM) for cancer-related cognitive impairment (CRCI) up to date. Methods: EMBASE, Pubmed and eight Korean databases were searched for clinical studies about TKM for CRCI up to July 2016. We selected articles about subjects with cancer, using TKM interventions including acupuncture, moxibustion or herbal medicine, containing assessment about cognitive function. Results: Two randomized controlled trials (RCTs) and one randomized controlled feasibility study were included. Selected studies were containing assessments about cognitive function but not as primary outcomes. The three studies included one acupuncture study and two herbal-medicine studies. Only one herbal-medicine study showed improvement in cognitive function. Conclusions: Few clinical studies mainly focusing CRCI treated with TKM have been performed and have shown contradictory results until now. Future studies should be performed considering findings from pre-clinical and clinical studies altogether, and they should be controlled to minimize risk of bias thorough out overall courses of designing, conducting and reporting them.

Keywords

References

  1. Denlinger CS, Ligibel JA, Are M, Baker KS, Demark-Wahnefried W, Friedman DL, et al., Survivorship: cognitive function, version 1.2014. Journal of the National Comprehensive Cancer Network : JNCCN. 2014;12(7):976-86. https://doi.org/10.6004/jnccn.2014.0094
  2. Cheung YT, Chui WK, Chan A. Neurocognitive impairment in breast cancer patients: pharmacological considerations. Critical reviews in oncology/hematology. 2012;83(1):99-111. https://doi.org/10.1016/j.critrevonc.2011.09.001
  3. Park JH, Bae SH, Jung YS, Jung YM. Prevalence and Characteristics of Chemotherapy -related Cognitive Impairment in Patients with Breast Cancer. J Korean Acad Nurs. 2015;45(1):118-28. https://doi.org/10.4040/jkan.2015.45.1.118
  4. Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, et al., American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016;34(6):611-35. https://doi.org/10.1200/JCO.2015.64.3809
  5. Wefel JS, Vardy J, Ahles T, Schagen SB. International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. The Lancet. Oncology. 2011;12(7):703-8. https://doi.org/10.1016/S1470-2045(10)70294-1
  6. Kohli S, Griggs JJ, Roscoe JA, Jean-Pierre P, Bole C, Mustian KM, et al., Self-reported cognitive impairment in patients with cancer. Journal of oncology practice / American Society of Clinical Oncology. 2007;3(2):54-9. https://doi.org/10.1200/JOP.0722001
  7. Ahles TA, Correa DD. Neuropsychological impact of cancer and cancer treatments. Psycho-oncology. 2010:251-7.
  8. Palmer JL, Trotter T, Joy AA, Carlson LE. Cognitive effects of Tamoxifen in pre-menopausal women with breast cancer compared to healthy controls. Journal of cancer survivorship : research and practice. 2008;2(4):275-82. https://doi.org/10.1007/s11764-008-0070-1
  9. Schilder CM, Seynaeve C, Beex LV, Boogerd W, Linn SC, Gundy CM, et al. Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010;28(8):1294-300. https://doi.org/10.1200/JCO.2008.21.3553
  10. Ahles TA, Saykin AJ, McDonald BC, Furstenberg CT, Cole BF, Hanscom BS, et al. Cognitive function in breast cancer patients prior to adjuvant treatment. Breast cancer research and treatment. 2008;110(1):143-52. https://doi.org/10.1007/s10549-007-9686-5
  11. Jansen CE, Cooper BA, Dodd MJ, Miaskowski CA. A prospective longitudinal study of chemotherapy-induced cognitive changes in breast cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2011;19(10):1647-56. https://doi.org/10.1007/s00520-010-0997-4
  12. Janelsins MC, Kesler SR, Ahles TA, Morrow GR. Prevalence, mechanisms, and management of cancer-related cognitive impairment. International review of psychiatry (Abingdon, England). 2014;26(1):102-13. https://doi.org/10.3109/09540261.2013.864260
  13. Wefel JS, Schagen SB. Chemotherapy-related cognitive dysfunction. Current neurology and neuroscience reports. 2012;12(3):267-75. https://doi.org/10.1007/s11910-012-0264-9
  14. Vardy J, Rourke S, Tannock IF. Evaluation of cognitive function associated with chemotherapy: a review of published studies and recommendations for future research. Journal of Clinical Oncology. 2007;25(17):2455-63. https://doi.org/10.1200/JCO.2006.08.1604
  15. Correa DD, Ahles TA. Neurocognitive changes in cancer survivors. Cancer journal (Sudbury, Mass.). 2008;14(6):396-400. https://doi.org/10.1097/PPO.0b013e31818d8769
  16. Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Gundy C, Schagen SB. Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. Journal of Clinical Oncology. 2012;30(10):1080-6. https://doi.org/10.1200/JCO.2011.37.0189
  17. de Ruiter MB, Reneman L, Boogerd W, Veltman DJ, Caan M, Douaud G, et al. Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging. Human brain mapping. 2012;33(12):2971-83. https://doi.org/10.1002/hbm.21422
  18. Deprez S, Amant F, Yigit R, Porke K, Verhoeven J, Van den Stock J, et al. Chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients. Human brain mapping. 2011;32(3):480-93. https://doi.org/10.1002/hbm.21033
  19. Kesler SR, Watson C, Koovakkattu D, Lee C, O'Hara R, Mahaffey ML, et al. Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy. Brain imaging and behavior. 2013;7(4):501-10. https://doi.org/10.1007/s11682-013-9228-1
  20. Janelsins MC, Mustian KM, Palesh OG, Mohile SG, Peppone LJ, Sprod LK, et al. Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2012;20(4):831-9. https://doi.org/10.1007/s00520-011-1158-0
  21. Ahles TA, Saykin AJ, Candidate mechanisms for chemotherapy-induced cognitive changes. Nature reviews. Cancer. 2007;7(3):192-201. https://doi.org/10.1038/nrc2073
  22. Raffa RB, A proposed mechanism for chemotherapy-related cognitive impairment ('chemo-fog'). Journal of clinical pharmacy and therapeutics. 2011;36(3):257-9. https://doi.org/10.1111/j.1365-2710.2010.01188.x
  23. Wefel JS, Kesler SR, Noll KR, Schagen SB. Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults. CA: a cancer journal for clinicians. 2015;65(2):123-38. https://doi.org/10.3322/caac.21258
  24. Ju C. Hwang Jae Nae Kyeong Yeongchu. Cheonghong. 2007.
  25. Committee for the textbook of Traditional Korean neuropsychiatry. Traditonal Korean medical Neuropsychiatry. Vol. 1. Jipmoon. 2007.
  26. Committee for the textbook of the acupuncture and moxibustion. Amnesia and Dementia. The acupuncture and moxibustion 3. Vol. 2. Jipmoon. 2008.
  27. Lee BH, Kim HY, Park JH, Yang TY, Jang EY, Jeon HS, et al. Effect of acupuncture on the short term memory. The journal of East-West medicine. 2015;40(3):13-23.
  28. Yun J, Kim Y, Lee C. A prison without bars: defect-punctured cancer-survivors management. Segye newspaper 2016. Available at: URL: http://www.segye.com/content/html/2016/07/06/20160706003541.html. Accessde July 6, 2016.
  29. Boykoff N, Moieni M, Subramanian SK. Confronting chemobrain: an in-depth look at survivors' reports of impact on work, social networks, and health care response. Journal of cancer survivorship : research and practice. 2009;3(4):223-32. https://doi.org/10.1007/s11764-009-0098-x
  30. Towler P, Molassiotis A, Brearley S. What is the evidence for the use of acupuncture as an intervention for symptom management in cancer supportive and palliative care: an integrative overview of reviews. Supportive Care in Cancer. 2013;21(10):2913-23. https://doi.org/10.1007/s00520-013-1882-8
  31. Liu F, Li ZM, Jiang YJ, Chen LD. A meta-analysis of acupuncture use in the treatment of cognitive impairment after stroke. Journal of alternative and complementary medicine (New York, N.Y.). 2014;20(7):535-44. https://doi.org/10.1089/acm.2013.0364
  32. Cao H, Wang Y, Chang D, Zhou L, Liu J. Acupuncture for vascular mild cognitive impairment: a systematic review of randomised controlled trials. Acupuncture in medicine : journal of the British Medical Acupuncture Society. 2013;31(4):368-74. https://doi.org/10.1136/acupmed-2013-010363
  33. Sun DZJ, Zhang JP, Xu X, Ye JY, Xiu M, Zhao LJ, et al. Therapeutic effect of Jinlongshe Granule () on quality of life of stage IV gastric cancer patients using EORTC QLQ-C30: A double-blind placebo-controlled clinical trial. Chinese journal of integrative medicine. 2015;21(8):579-86. https://doi.org/10.1007/s11655-014-1950-z
  34. Chan KKY, Jones, TJ, Zhao B, Ma JF, Leung FK, Lau CY, et al. The use of Chinese herbal medicine to improve quality of life in women undergoing chemotherapy for ovarian cancer: a double-blind placebo-controlled randomized trial with immunological monitoring. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2011;22(10):2241-9. https://doi.org/10.1093/annonc/mdq749
  35. Johnston MFH, Subramanian RD, Elashoff SK, Axe RM, Li EK, Kim JJ, et al. Patient education integrated with acupuncture for relief of cancer-related fatigue randomized controlled feasibility study. BMC complementary and alternative medicine. 2011;11:49. https://doi.org/10.1186/1472-6882-11-49
  36. Yun YH, Park YS, Lee ES, Bang SM, Heo D, Park S, et al., Validation of the Korean version of the EORTC QLQ-C30. Quality of Life Research. 2004;13(4):863-8. https://doi.org/10.1023/B:QURE.0000021692.81214.70
  37. Deng M, Wang XF. Acupuncture for amnestic mild cognitive impairment: a meta-analysis of randomised controlled trials. Acupuncture in Medicine. 2016:acupmed-2015-010989.
  38. Hwang D, Bang-Yak-Hap-Pyun(方藥合編). Younglim. 2010.
  39. LI Cj, WEI Pk, YU Bl. Study on the mechanism of Xiaotan Sanjie Recipe for inhibiting proliferation of gastric cancer cells. Journal of Traditional Chinese Medicine. 2010;30(4):249-53. https://doi.org/10.1016/S0254-6272(10)60051-9
  40. Joo SK, Kim GW, Goo BS, Kim CH. Effects of Arisaematics rhizoma on Ischemic Damage and Cytotoxicity in Brain. Journal of Korean Medicine. 2001;2(1).
  41. Won HY, Choi CW, Kim KS, Kim KO, Lee DW, Kim SY. The effects of Banhabaekchulchunma -Tang (BCT) on Dementia induced by focal brain ischemic injury in rats. Journal of Oriental Neuropsychiatry. 2006;17(2):61-73.
  42. Kim S, Ryu B, Ryu K, Park D. Study of anti-cancer effects of Cremastrae Appendiculatae Tuber on stomach cancer cells. J. Korean Oriental Med. 2001;22(2):75-83.
  43. Seo B, Lee E. A Philological Study on poisoning of Pseudobulbus Cremastrae Appendiculatae. Journal of applied oriental medicine. 2003;3(1):73-82.
  44. Kim H, Hong S. The anti-inflammatory effects of Huang-Lyun (Coptidis Rhizoma, CR) on injured tissue after burn elicitation. J Korean Oriental Med. 2011;32(2):1-13.
  45. Jeong MY, Kim YH, Lee NK, Lee JY, Herr Y, Lee JH, et al., Antimicrobial effect on the periodontal pathogens and anti-inflammatory effect of Eriobotryae Folium. J Korean Orient Med. 2008;29:182-92.
  46. Avisar AR, Schiff Y, Bar-Sela E, Steiner G, Ben-Arye M. Chemotherapy-related cognitive impairment: does integrating complementary medicine have something to add? Review of the literature. Breast cancer research and treatment. 2012;136(1):1-7. https://doi.org/10.1007/s10549-012-2211-5
  47. Johnston MFY, Hui C, Xiao KK,, Li B, Rusiewicz X. Acupuncture for chemotherapy-associated cognitive dysfunction: a hypothesis-generating literature review to inform clinical advice. Integrative cancer therapies. 2007;6(1):36-41. https://doi.org/10.1177/1534735406298903
  48. Yu SJ, Tseng J, Ling Fu. a Chinese herbal drug, modulates cytokine secretion by human peripheral blood monocytes. International journal of immunopharmacology. 1996;18(1):37-44. https://doi.org/10.1016/0192-0561(95)00103-4
  49. Sparkman NL, Buchanan JB, Heyen JR, Chen J, Beverly JL, Johnson RW. Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. The Journal of neuroscience. 2006;26(42):10709-16. https://doi.org/10.1523/JNEUROSCI.3376-06.2006
  50. O'Sullivan E, Higginson I. Clinical effectiveness and safety of acupuncture in the treatment of irradiation-induced xerostomia in patients with head and neck cancer: a systematic review. Acupuncture in Medicine. 2010;28(4):191-9. https://doi.org/10.1136/aim.2010.002733
  51. Sun X, Zhang X, Nian JY, Guo J, Yin Y, Zhang GL, et al. Chinese Herbal Medicine as Adjunctive Therapy to Chemotherapy for Breast Cancer: A Systematic Review and Meta-Analysis. Evidence-based complementary and alternative medicine : eCAM. 2016;2016:3281968.

Cited by

  1. 한양방결합치료로 장기간 생존하고 있는 교모세포종 증례 보고 vol.39, pp.1, 2016, https://doi.org/10.13048/jkm.18008
  2. Characteristics of Inpatients Who Survive Suicide Attempts vol.10, pp.1, 2019, https://doi.org/10.24171/j.phrp.2019.10.1.07
  3. HMT Exerts an Anticancer Effect by Targeting PAK-1 vol.11, pp.13, 2016, https://doi.org/10.3390/app11136034