한국융합학회논문지 (Journal of the Korea Convergence Society)

  • 제8권4호
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  • Pages.123-129
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  • 2017
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  • 2233-4890(pISSN)
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  • 2713-6353(eISSN)
한국융합학회 (Korea Convergence Society)
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섬유화된 간조직에서 알파토코페롤에 따른 조직학적 변화 연구

A study of Histological changes by α-tocopherol in the hepatic fibrous tissue

  • 김진수 (대전보건대학교 임상병리과)
  • Kim, Jean-Soo (Department of Clinical Laboratory Science, Daejeon Health Institute of Technology)
  • 투고 : 2017.03.14
  • 심사 : 2017.04.20
  • 발행 : 2017.04.28
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초록

본 연구는 섬유화 된 간조직의 조직학적 변화를 알아보고 알파토코페롤에 대한 영향을 보고자 실시 하였다. 실험군은 3군으로 나누어 사염화탄소로 섬유화 유발한 실험군과 알파토코페롤과 사염화탄소를 같이 투여한 실험군 그리고 정상군으로 나누어 실험하였다. 검사 결과는 알파토코페롤 투여군에서는 사염화탄소만 투여 했던 실험군에 비하여 간 조직의 경화와 관련된 섬유화 반응이 약한 것을 알 수 있었다. 결론적으로 섬유화 된 간조직에서 ALT, AST, ALP등의 증가와 헤마톡실린 에오진 염색과 마손 삼색 염색을 통한 아교 섬유의 증식을 관찰 할 수 있었으며 알파토코페롤의 섭취에 따른 융합 항산화 작용을 알 수 있었다. 따라서 본 연구 결과를 통하여 간 질환진단의 임상적 의의와 보조 치료제로서의 알파토코페롤의 활용을 기대 할 수 있을 것이라고 사료된다.

This study has been conducted to see influence of fibroid hepatic tissue on alpha-tocopherol and its histologic changes. Experimental groups were divided into 3 groups, one where fibrosis was caused by carbon tetrachloride and the other where alpha-tocopherol and carbon tetrachloride were administered together and another normal group. Results of test showed fibrosis reaction is weak compared to the group administered with carbon tetrachloride in the group administered with alpha-tocopherol. In conclusion, we could observe proliferation of collagen fibers through Hematoxylin&Eosin and Massom trichrom dye and increase in ALT, AST, ALP in fibroid hepatic tissues, indicating convergence anti-oxidation reaction by changes of alpha-tocopherol intake. Thus, it is considered that we can expect to utilize alpha-tocopherol as secondary treatment and find clinical meanings of diagnosis on hepatic diseases through results of this study.

키워드

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