The Korean Journal of Emergency Medical Services (한국응급구조학회지)

The Korea Society of Emergency Medical Services (한국응급구조학회)
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Effect of alcohol on norepinephrine-induced vasoconstriction

알코올이 노르에피네프린에 의한 혈관 수축에 미치는 영향

  • Kang, Myeongsin (Department of Emergency Medical Services, Eulji University) ;
  • Jeon, Min-A (Department of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine) ;
  • Eun, Seo Hyeon (Department of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine) ;
  • Choi, Hea Kyung (Department of Emergency Medical Services, Eulji University) ;
  • Park, Sang Woong (Department of Emergency Medical Services, Eulji University)
  • 강명신 (을지대학교 응급구조학과) ;
  • 전민아 (건국대학교 의과대학 생리학교실) ;
  • 은서현 (건국대학교 의과대학 생리학교실) ;
  • 최혜경 (을지대학교 응급구조학과) ;
  • 박상웅 (을지대학교 응급구조학과)
  • Received : 2019.11.08
  • Accepted : 2019.12.13
  • Published : 2019.12.31
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Abstract

Purpose: Norepinephrine (NE) is a neurotransmitter of the sympathetic nervous system. It is used for treating hypotension on distributive shock, central nervous system injury, or sepsis. There are several reports that state that alcohol suppresses vasoconstriction by NE. Thus, our hypothesis is that the effect of NE is reduced in alcohol-drinking patients with distributive shock. We investigated whether alcohol suppresses NE-induced contraction and aimed at finding a solution to this problem. Methods: For this study, we used the aorta from male Sprague-Dawley rats (9-11 weeks) and an isometric contraction system. Results: Our results showed that alcohol suppresses NE contraction and does not affect epinephrine induced a contraction. Moreover, in the presence of alcohol, a 7:3 mixture of NE and epinephrine induced a contractile force similar to that induced by NE under normal conditions. Conclusion: We found that the vasoconstrictive force of NE decreased in the blood vessels in which alcohol was present, which was not because endothelial cells. The reduced contractile force was most similar to that induced by a 7:3 mixture of NE and epinephrine.

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