The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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A Cross-sectional Study of Deficiency-Excess Pattern Identification with Blood Cytokines and Characteristics of Patients with Asthma

천식환자 허실변증별 혈액 싸이토카인 및 임상적 특성에 관한 단면적 연구

  • Yu, Chang-hwan (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School of Korean Medicine, Kyung Hee University) ;
  • Kang, Sung-woo (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School of Korean Medicine, Kyung Hee University) ;
  • Hong, Sung-eun (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School of Korean Medicine, Kyung Hee University) ;
  • Kim, Kwan-il (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School of Korean Medicine, Kyung Hee University) ;
  • Lee, Beom-joon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School of Korean Medicine, Kyung Hee University) ;
  • Jung, Hee-jae (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School of Korean Medicine, Kyung Hee University)
  • 유창환 (경희대학교대학원 임상한의학과 폐계내과학교실) ;
  • 강성우 (경희대학교대학원 임상한의학과 폐계내과학교실) ;
  • 홍성은 (경희대학교대학원 임상한의학과 폐계내과학교실) ;
  • 김관일 (경희대학교대학원 임상한의학과 폐계내과학교실) ;
  • 이범준 (경희대학교대학원 임상한의학과 폐계내과학교실) ;
  • 정희재 (경희대학교대학원 임상한의학과 폐계내과학교실)
  • Received : 2020.08.21
  • Accepted : 2020.09.21
  • Published : 2020.09.30
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Abstract

Objective: The aims of this study were to analyze deficiency-excess pattern identification and to compare the blood cytokines in patients with asthma. Methods: A total of 112 patients with asthma who met the inclusion and exclusion criteria were divided into deficiency syndrome and excess syndrome groups. Blood was examined for eotaxin, interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-α. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), a Visual Analogue Scale (VAS), and heart rate variability (HRV) tests were administered to both groups. Results: Pattern identification divided the 112 patients into two categories: a deficiency syndrome group (N=52) and an excess syndrome group (N=60). Analysis of blood cytokines showed higher levels of IL-4, IL-5, and IL-13 in the deficient pattern than in the excess pattern group, but the difference was not statistically significant. Analysis of the HRV revealed a significantly higher mean value for the very-low-frequency (VLF) and high-frequency (HF) bands in the deficiency than in the excess syndrome group. The morbidity duration was longer in the deficiency than in the excess syndrome group, but the difference was not statistically significant. Analysis of the QLQAKA and VAS scores showed a negative correlation, whereas BMI and VAS showed a positive correlation. Conclusions: Levels of blood cytokines, including eotaxin, IL-1β, IL-4, IL-5, IL-6, IL-13, and TNF-α, did not differ statistically between the deficiency and excess syndrome groups. The development of a more accurate asthma-specific pattern identification tool would be useful in asthma control.

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