대한약침학회지 (Journal of Pharmacopuncture)

  • 제26권4호
  • /
  • Pages.338-347
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  • 2023
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  • 2093-6966(pISSN)
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  • 2234-6856(eISSN)
대한약침학회 (KOREAN PHARMACOPUNCTURE INSTITUTE)
권호 표지
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Inhibition of Glycation End Products Formation and Antioxidant Activities of Ilex paraguariensis: comparative study of fruit and leaves extracts

  • Laura Cogoi (Pharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires) ;
  • Carla Marrassini (Pharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires) ;
  • Elina Malen Saint Martin (Pharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires) ;
  • Maria Rosario Alonso (Institute of Chemistry and Drug Metabolism (IQUIMEFA), CONICET-University of Buenos Aires) ;
  • Rosana Filip (Pharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires) ;
  • Claudia Anesini (Pharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires)
  • 투고 : 2023.08.25
  • 심사 : 2023.11.19
  • 발행 : 2023.12.31
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초록

Objectives: Ilex paraguariensis (Aquifoleaceae) is cultivated to produce "yerba mate". Due to its nutritional, energizing, hypoglycemic and antioxidant effects, it is used in the elaboration of food, pharmaceuticals, and cosmetics. The oxidative stress related to protein glycation and production of advanced glycation end products (AGEs) leads to the development of several diseases. The objective of this work was to compare the antioxidant and anti-AGEs activity of a decoction of fruits (F) and leaves (L). Methods: The antioxidant activity was assayed by the DPPH assay and the inhibition of egg yolk lipid peroxidation (ILP), and anti-AGEs activity, through the inhibition of the formation of fructosamine (IF), β-amyloid (Iβ), protein carbonylation (IC) and AGEs (IA). Polyphenols were quantified by HPLC. Results: Maximum response ± SEM: For F 0.01 ㎍/mL: IF = 42 ± 4%, IC = 17 ± 2% and for 10 ㎍/mL: IA = 38 ± 4%, Iβ = 67 ± 7%. For L 0.1 ㎍/mL: IF = 35 ± 2%, IC = 19 ± 2% and for 100 ㎍/mL: IA = 26 ± 3%, Iβ = 63.04 ± 2%. The DPPH IC50 = 134.8 ± 14 ㎍/mL for F and 34.67 ± 3 ㎍/mL for L. The ILP IC50 = 512.86 ± 50 ㎍/mL for F and 154.8 ± 15 ㎍/mL for L. By HPLC L presented the highest amounts of flavonoids and caffeoylquinic acids. F and L showed strong anti-AGEs activity, affecting the early stages of glycation at low concentrations and the late stages of glycation at high concentrations. The highest activity for both F and L was seen in the IF and Iβ. F presented the highest anti-AGEs potency. L presented the highest antioxidant potency, which was related to the highest content of polyphenols. Conclusion: The fruits of I. paraguariensis could be a source of antioxidant and anti-AGEs compounds to be used with medicinal purposes or as functional food.

키워드

과제정보

This work was supported by PIP 00067 from CONICET and UBACYT 20020130100686BA from Universidad de Buenos Aires.

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