Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지
DOI QR코드

DOI QR Code

Allergic effects of Der p 38 and Der f 38: A Comparison

  • Ji-Sook Lee (Department of Clinical Laboratory Science, Wonkwang Health Science University)
  • Received : 2023.04.21
  • Accepted : 2023.08.31
  • Published : 2023.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Asthma is a chronic and allergic inflammation in the lung, mainly caused by house dust mites (HDM). Recent studies have reported Der p 38 and Der f 38 (Dermatophagoides pteronyssinus and D. farinae, respectively) as crucial allergens of HDMs. This study investigates the different allergic effects of Der p 38 and Der f 38 in an asthma-like mouse model. Lung infiltration of neutrophils was induced by intranasal administration of Der p 38 and Der f 38, with stronger infiltration being observed after exposure to Der p 38. Intranasal and intraperitoneal administration of Der p 38 induced the infiltration of neutrophils and eosinophils in the lung, which was similar to the effect subsequent to Der f 38 administration. Although the number of mast cells was increased, no significant difference was obtained between the effects of both allergens. In TLR4 knockout BALB/c mice, Der p 38 and Der f 38 had no effect on the infiltration of neutrophils, eosinophils, and mast cells. Additionally, allergenicity induced by Der p 38 and Der f 38 in the basophils of Der p38+/Der f 38+ asthmatic subjects was similar, although Der f 38 presented stronger allergenicity in basophils of Der p38+/Der f 38+ allergic patients than Der p 38. These findings contribute to understanding the role of similar allergen components derived from different species in the pathogenesis of allergic diseases.

Keywords

Acknowledgement

This paper was supported by Wonkwang Health Science University in 2023.

References

  1. Aun MV, Bonamichi-Santos R, Arantes-Costa FM, Kalil J, Giavina-Bianchi P. Animal models of asthma: utility and limitations. Journal of Asthma and Allergy. 2017. 10: 293-301. https://doi.org/10.2147/JAA.S121092
  2. Hong MH, Kashif A, Kim G, Park BS, Lee NR, Yang EJ, Mun JY, Choi H, Kim SH, Kim HJ, Lee SJ, Lee JS, Hong Y, Kim IS. Der p 38 is a bidirectional regulator of eosinophils and neutrophils in allergy. The Journal of Immunology. 2021. 207: 1735-1746. https://doi.org/10.4049/jimmunol.2001144
  3. Jacquet A. The role of the house dust mite-induced innate immunity in development of allergic response. International Archives of Allergy and Immunology. 2011. 155: 95-105. https://doi.org/10.1159/000320375
  4. Jeon H, Kim G, Kashif A, Hong MH, Lee JS, Hong Y, Park BS, Yang EJ, Kim IS. Pathogenic Mechanism of Der p 38 as a Novel Allergen Homologous to RipA and RipB Proteins in Atopic Dermatitis. Frontiers in Immunology. 2021. 2: 646316.
  5. Jo KM, Lim HK, Sull JW, Choi E, Lee JS, Cheong MA, Hong MH, Kim Y, Kim IS. Thymus and activation-regulated chemokine (TARC)/CCL17 and IgE are associated with elderly asthmatics. Immunity and Ageing. 2018. 15: 13.
  6. Kim G, Hong M, Kashif A, Hong Y, Park BS, Mun JY, Choi H, Lee JS, Yang EJ, Woo RS, Lee SJ, Yang M, Kim IS. Der f 38 is a novel TLR4-binding allergen related to allergy pathogenesis from Dermatophagoides farinae. International Journal of Molecular Sciences. 2021. 22: 8440.
  7. Lee JS. Anti-inflammatory effects of neuregulin-1 via the downregulation of IL-6, IL-8, and MCP-1 secretion. Biomedical Science Letters. 2022. 28: 192-194. https://doi.org/10.15616/BSL.2022.28.3.192
  8. Miller JD. The Role of Dust Mites in Allergy. Clinical Review in Allergy and Immunology. 2019. 57: 312-329. https://doi.org/10.1007/s12016-018-8693-0
  9. Sudharson S, Kalic T, Hafner C, Breiteneder H. Newly defined allergens in the WHO/IUIS Allergen Nomenclature Database during 01/2019-03/2021. Allergy. 2021. 76: 3359-3373. https://doi.org/10.1111/all.15021