• Title, Summary, Keyword: $Sj{\ddot{o}}gren^{\prime}s$ syndrome

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A Case Report of Sjögren's Syndrome with Influenza A Virus Infection Treated with Korean Medicine (A형 독감을 동반한 쇼그렌 증후군 환자에 대한 한의치료 1례)

  • Lee, Gi-hyang;Jeon, Sang-woo;Kang, Sei-young
    • The Journal of Internal Korean Medicine
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    • v.40 no.5
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    • pp.1007-1013
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    • 2019
  • Objectives: The purpose of this study was to report the treatment of a patient suffering from $Sj{\ddot{o}}gren^{\prime}s$ Syndrome with influenza A virus infection with Korean medicine. Methods: We used herbal medicine, acupuncture, and moxibustion to treat a patient during hospitalization. We observed the changes in symptoms using the European League against Rheumatism $Sj{\ddot{o}}gren^{\prime}s$ Syndrome Patient Reports Index (ESSPRI) and a visual analogue scale (VAS). Results: After treatment for 17 days, the patient's symptoms showed improvement in joint pain, dry eye, and dry mouth. The ESSPRI score was decreased from 10 to 5.3. The VAS for dry mouth and dry eye were decreased from 10 to 6 and from 10 to 5, respectively. Conclusion: This clinical case study suggests that Korean medicine treatment that includes Insamyangyoung-tang-gami could be effective in the treatment of $Sj{\ddot{o}}gren^{\prime}s$ Syndrome.

Sjögren's Syndrome: an Update on Diagnostic, Clinical, and Basic Aspects for Oral Medicine Specialists

  • Lee, Kyung-Eun
    • Journal of Oral Medicine and Pain
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    • v.43 no.4
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    • pp.99-111
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    • 2018
  • $Sj{\ddot{o}}gren^{\prime}s$ syndrome (SjS) is a common autoimmune disorder characterized by lymphocytic infiltration in the salivary and lacrimal glands, resulting in severe dry mouth or eyes. As a result, most of SjS patients suffer from oral dryness and can visit the department of oral medicine with or without diagnosis of SjS. Therefore, oral medicine specialists should know clues, which may indicate the diagnosis of SjS from the clinical and laboratory investigations. By the recent SjS criteria, SjS can be diagnosed by focus score, ocular staining, Schirmer's test, unstimulated whole saliva flow rate, and anti-SSA/Ro antibodies. The aim of this article is to review the diagnostic criteria, clinical investigation, and basic aspect related to SjS and to make oral medicine specialists play an important role in the detection of emerging SjS.

Rehabilitation using twin-stage method for a Sjögren's syndrome patient with severe discoloration and attrition on upper and lower anterior teeth (상하악 전치부 심한 변색과 마모를 보이는 쉐그렌 증후군 환자에서 twin-stage법을 이용한 수복증례)

  • Lee, Seon-Ki;Yang, Hong-So;Park, Sang-Won;Lim, Hyun-Pil;Yun, Kwi-Dug
    • The Journal of Korean Academy of Prosthodontics
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    • v.54 no.3
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    • pp.291-297
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    • 2016
  • Patients with $Sj{\ddot{o}}gren^{\prime}s$ syndrome usually suffer from teeth discoloration and attrition due to xerostomia. If the anterior teeth are badly worn, problems such as loss of anterior guidance, occlusal disharmony, and limited space for restoration may occur. However, ideal occlusion is obtained in both centric and eccentric relation by regaining the disocclusion of the posterior teeth through the anterior and lateral guidance using twin-stage method. In this case, rehabilitation was performed for a $Sj{\ddot{o}}gren^{\prime}s$ syndrome patient with maxillary and mandibular incisor's severe attrition and teeth discoloration by using twin-stage method.

Correlation between Tear Osmolarity and Other Ocular Surface Parameters in Primary Sjögren's Syndrome

  • Kim, Mirinae;Kim, Hyun Seung;Na, Kyung-Sun
    • Korean Journal of Ophthalmology
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    • v.31 no.1
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    • pp.25-31
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    • 2017
  • Purpose: To investigate the relationships between tear osmolarity and other ocular surface parameters and to determine the diagnostic value of tear osmolarity in primary $Sj{\ddot{o}}gren^{\prime}s$ syndrome (SS) using tear film break-up time, Schirmer I test, and cornea/conjunctiva staining. Methods: We included 310 eyes of 155 patients diagnosed with dry eye disease (39 primary SS and 116 non-$Sj{\ddot{o}}gren$ dry eye disease) at Seoul St. Mary's Hospital from August 2010 to January 2015. All subjects completed the Ocular Surface Disease Index (OSDI) questionnaire and underwent ocular examinations including tear osmolarity (TearLab Osmolarity System), Schirmer I test, slit lamp examination for tear film break-up time, and corneal and conjunctival fluorescein staining. We used the mean value of both eyes for all parameters. Fluorescein staining was assessed using the $Sj{\ddot{o}}gren^{\prime}s$ International Collaborative Clinical Alliance ocular staining score (OSS). Results: In primary SS patients (n = 39), the mean subject age was $52.5{\pm}11.9$ years, and 94.9% of the subjects were women. Mean tear osmolarity in SS was $311.1{\pm}16.4mOsm/L$, with 16 (41.0%) subjects having values ${\geq}316mOsm/L$. In SS, there was a positive correlation between mean tear osmolarity and OSDI score (${\rho}=0.405$, p = 0.011) and OSS (${\rho}=0.592$, p < 0.001). There was a negative correlation between mean tear osmolarity and the Schirmer I test (${\rho}=-0.625$, p < 0.001). There was no significant correlation between mean tear osmolarity and tear film break-up time in SS (${\rho}=0.110$, p = 0.505). Conclusions: Tear osmolarity measurements using the TearLab Osmolarity System can reflect both symptom severity (OSDI) and objective signs (Schirmer test and OSS) in SS.

Motor dominant polyradiculopathy with Primary Sjögren's syndrome mimicking motor neuron disease

  • Ahn, Suk-Won;Yoon, Byung-Nam
    • Annals of Clinical Neurophysiology
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    • v.21 no.1
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    • pp.61-65
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    • 2019
  • $Sj{\ddot{o}}gren^{\prime}s$ syndrome (SS)-associated polyradiculopathy is rarely reported. A 51-year-old woman presented with a history of gradual weakness in all four extremities for several months. Based on electrophysiological studies, spinal magnetic resonance imaging and cerebrospinal fluid examination, inflammatory polyradiculopathy was confirmed. During a search for the aetiology, the patient was ultimately diagnosed with SS. This study introduces SS-associated polyradiculopathy that primarily presented with motor symptoms, thus mimicking motor neuron disease.

A Case Reports of a Patient with Sjogren's Syndrome Treated with Gami-onchung-eum (가미온청음으로 호전된 쇼그렌 증후군 환자 치험 1례)

  • Jeong, Yeong-eun;Park, Chung-a;Kim, Jong-dea
    • The Journal of Internal Korean Medicine
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    • v.38 no.5
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    • pp.763-768
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    • 2017
  • Objectives: The purpose of this study is to report the clinical effectiveness of Korean medicine, especially Gami-onchung-eum, for treatment of a patient with Sjogren's syndrome. Methods: The patient, diagnosed with Sjogren's syndrome, was suffering from systemic symptoms accompanied by dry mouth, dry eye, and fatigue. We treated her with Korean medicine involving a herbal decoction, acupuncture, moxibustion, and cupping. We used the European League Against Rheumatism $Sj{\ddot{o}}gren^{\prime}s$ Syndrome Patient Reported Index for assessment. Results: Based on the European League Against Rheumatism $Sj{\ddot{o}}gren^{\prime}s$ Syndrome Patient Reported Index, after 28 days of treatment, dry mouth decreased to a score of 5, dry eye decreased to 2, and fatigue decreased to 3. Conclusions: Korean medicine, including Gami-onchung-eum, may be an effective treatment for Sjogren's syndrome.

A Case of Lung Involvement Showing Multiple Lung Cysts in Primary Sjögren's Syndrome (다발성 폐 낭종을 보인 쇼그렌 증후군의 폐 침범 1예)

  • Kim, Ji Yon;Hwang, Hyun Gyu;Choi, Jae Sung;Seo, Ki Hyun;Kim, Yong Hoon;Oh, Mee Hye;Na, Ju Ock
    • Tuberculosis and Respiratory Diseases
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    • v.64 no.3
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    • pp.230-235
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    • 2008
  • We described herein the first case of primary $Sj{\ddot{o}}gren^{\prime}s$ syndrome in Korea which presented with multiple cysts caused by only peribronchiolar lymphocytic infiltration, a rare pulmonary manifestation in $Sj{\ddot{o}}gren^{\prime}s$ syndrome, and was confirmed by surgical lung biopsy. A brief review of the literature has been included.

Renal Tubular Acidosis in Patients with Primary Sjögren's Syndrome

  • Jung, Su Woong;Park, Eun Ji;Kim, Jin Sug;Lee, Tae Won;Ihm, Chun Gyoo;Lee, Sang Ho;Moon, Ju-Young;Kim, Yang Gyun;Jeong, Kyung Hwan
    • Electrolytes & blood pressure
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    • v.15 no.1
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    • pp.17-22
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    • 2017
  • Primary $Sj{\ddot{o}}gren^{\prime}s$ syndrome (pSS) is characterized by lymphocytic infiltration of the exocrine glands resulting in decreased saliva and tear production. It uncommonly involves the kidneys in various forms, including tubulointerstitial nephritis, renal tubular acidosis, Fanconi syndrome, and rarely glomerulonephritis. Its clinical symptoms include muscle weakness, periodic paralysis, and bone pain due to metabolic acidosis and electrolyte imbalance. Herein, we describe the cases of two women with pSS whose presenting symptoms involve the kidneys. They had hypokalemia and normal anion gap metabolic acidosis due to distal renal tubular acidosis and positive anti-SS-A and anti-SS-B autoantibodies. Since one of them experienced femoral fracture due to osteomalacia secondary to renal tubular acidosis, an earlier diagnosis of pSS is important in preventing serious complications.

Lymphocytic interstitial pneumonia in a patient with Sjögren's syndrome

  • Lee, Eun Hye;Park, Ji Eun;Goag, Eun Kyong;Kim, Young Joo;Jung, In Young;Kim, Chi Young;Park, Young Mok;Lee, Jung Mo;Park, Moo Suk
    • Yeungnam University Journal of Medicine
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    • v.33 no.2
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    • pp.112-115
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    • 2016
  • Lymphocytic interstitial pneumonia (LIP) is a rare benign lymphoproliferative disorder characterized by diffuse infiltration of the pulmonary parenchymal interstitium by polyclonal lymphocytes and plasma cells. LIP has been associated with a variety of clinical conditions; such as connective tissue disorders and other immune system abnormalities. Treatment usually involves administration of corticosteroids and other immunosuppressants. We report on a 38-year-old female patient who complained of shortness of breath, dry mouth, and dry eyes for more than 1 month, and was positive for Raynaud's phenomenon. Based on surgical biopsy, she was diagnosed as having LIP accompanied by $Sj{\ddot{o}}gren^{\prime}s$ syndrome. The patient was treated with high-dose steroids followed by maintenance therapy for approximately 2 years, and her condition improved.