Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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The Radioprotective Effect of Sam-Ryung-Baek-Chul-San (San-Ling-Bai-Shu-San) as a Prescriptions of Traditional Chinese Medicine in Irradiated Mice

방사선 피폭 마우스에서 삼령백출산 및 구성단미의 방호효과

  • Lee, Song-Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Oh, Heon (College of Veterinary Medicine, Chonnam National University) ;
  • Yang, Jung-Ah (College of Veterinary Medicine, Chonnam National University) ;
  • Chung, Chi-Young (College of Veterinary Medicine, Chonnam National University) ;
  • Jang, Jong-Sik (Dept. of Animal Science, Sangju National University) ;
  • Jo, Sung-Kee (Food Irradiation Team, Korea Atomic Energy Research Institute) ;
  • Byun, Myung-Woo (Food Irradiation Team, Korea Atomic Energy Research Institute) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University)
  • 이송은 (전남대학교 수의과대학) ;
  • 오헌 (전남대학교 수의과대학) ;
  • 양정아 (전남대학교 수의과대학) ;
  • 정치영 (전남대학교 수의과대학) ;
  • 장종식 (상주대학교 축산학과) ;
  • 조성기 (한국원자력연구소 방사선식품공학팀) ;
  • 변명우 (한국원자력연구소 방사선식품공학팀) ;
  • 김성호 (전남대학교 수의과대학)
  • Published : 1999.04.01
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Abstract

We performed this study to determine the radioprotective effect of Sam Ryung Baek Chul San (San Ling Bai Shu San), as a prescription of traditional Oriental medicine, and its major ingredients. Jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in irradiated mice with high and low dose of rays. Sam Ryung Baek Chul San administration before irradiation increased the formation of endogenous spleen colony(p<0.05) and reduced the frequency of radiation induced apoptosis(p<0.05). In the experiment on the effect of ingredients of Sam Ryung Baek Chul San, the result indicated that the extracts of Panax ginseng, Poria cocos and Coix lacryma jabi might have the major radioprotective effects. Although the mechanisms of these inhibitory effects remain to be elucidated, these results indicated that Sam Ryung Baek Chul San might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

Keywords

References

  1. IAEA safety series No. 47 Manual on Early Medical Treatment of Possible Radiation Injury IAEA
  2. NCP report No. 65 Management of Persons Accidentally Contaminated with Radionuclides NCP
  3. Science v.110 Cystein protects against x-irradiation Patt, H.;Tyree, M.;Straube, R. L.
  4. Cancer Res. v.42 Protective effects of S-2-(3-aminopropylamino) ethylphosphorothioec acid against radiation damage of normal tissues and a fibrosarcoma in mice Milas, L.;Hunter, N.;Reid, B. O.;Thames, Jr. H. D.
  5. Pharmacol. Ther. v.39 Radioprotectors in tumor radiotherapy : Factors and settings determining therapeutic ratio Milas, L.;Murray, D.;Brock, W. A.;Meyn, R. E.
  6. J. Immunol. v.136 Interleukin 1 is a radioprotector Neta, R.;Douches, S.;Oppenheim, J. J.
  7. Pharmacol. Ther. v.39 Role of cytokines in radioprotection Neta, R.
  8. Int. J. Radiat. Biol. v.57 Therapeutic use of recombinant human G-CSF(rhG-CSF) in a canine model of sublethal and lethal whole body irradiation MacVittie, T. J.;Monroy, R. L.;Patchen, M. L.;Souza, L. M.
  9. A survey of compounds from the antiradiation drug development program of the U.S. army medical research & development command. Sweeney, T. R.
  10. Cancer Clin. Trials v.3 PhaseⅠclinical studies with WR2721. Kligerman, M. M.;Shaw, M. T.;Slavid, M.;Yudas, J. M.
  11. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.12 Immunological and hematopoietic effect of Codonopsis pilosula on cancer patients during radiotherapy Zneg, X. L.;Li, X. A.;Zhang, B. Y.
  12. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.12 Clinical and experimental study on shen-qiinjection with chemotherapy in the treatment of malihnant tumor of digestive tract Li, N. Q
  13. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.17 Studies of Rehmannia glutinosa Libosch. F. hueichingensis as a blood tonic Yuan, Y.;Hou, S.;Lian, T.;Han, Y.
  14. Chin. Med. J. Engl. v.104 Advances in the pharmacological studies of radix Angelica sinensis(Oliv) Diels(Chinese Kanggui) Mei, Q. B.;Tao, T. Y.;Cui, B.
  15. Exp. Hematol. v.16 Radioprotection of hemopoiesis conferred by Acanthopanax xentiocosus Harms(Shigoka) administered before or after irradiation Miyanomae, T.;Frindel, E.
  16. Chung-Hua-I-Hsueh-Tsa-Chih v.76 The effect of angelica polysaccharide on proliferation and differentiation of hematopoietic progenitor cell Wang, Y.;Zhu, B.
  17. Yao Hsueh Hsueh Pao v.28 Effects of Phytolacca acinosa polysaccharidesⅡon lymphocyte proliferation and colony stimulating factor production from mice-splenocytes in vitro Wang, H. B.;Zheng, Q. Y.;Ju, D. W.;Fang, J.
  18. Yakugaku Zasshi v.110 Studies on chemical protectors against radiation.ⅩⅩⅩ. Radioprotective substances of cnidii rhizoma. Ohta, S.;Sakurai, N.;Sato, Y.;Inoue, T.;Shinoda, M.
  19. Am. J. Chin. Med. v.18 Radioprotective effect of Ganoderma lucidum(Leyss. ex. Fr.) Karst after X-ray irradiated mice Hsu, H. Y.;Lian, S. L.;Lin, C. C.
  20. Chung-Kuo-Chung-Yao-Tsa-Chih v.19 Effects of radix Astragali on hemopoiesis in irradiated mice Quan, H. X.;Li, H. S.
  21. Int. J. Cancer v.62 Interleukin-11 protects the clogenic stem coll in murine small-intestinal crypts from impairment of their reproductive capacity by radiation Potten, C. S.
  22. J. Histochem. Cytochem. v.41 A new method to detect apoptosis in paraffin section: In situ end-labeling of fragmented DNA Wijsman, J. H.;Jonker, R. R.;Keijzer, R.;Van Velde, C. J. H.;Corneliess, C. J.;Van Dierendonck, J. H.
  23. Radiat. Res. v.59 Distribution of WR-2721 in normal and malignent tissue of mice and rats bearing solid tumors: dependence on tumor type, drug dose and species Washburn, L. C.;Carlton, J. E.;Hayes, R. L.
  24. Radiat. Res. v.94 Adverse effect of radioprotector WR2721 Cairnie, A. B.
  25. J. Ethnopharmacol. v.52 Protection of mouse bone marrow by Si-Wu-Tang against whole body irradiation Hsu, H. Y.;Ho, Y. H.;Lin, C. C.
  26. Int. J. Immunopharmacol. v.16 Recipient-mediated effect of a traditional Chinese herbal medicine, ren-shen-yang-rong-tang(Japanese name: nunjin-youei-to), on hematopoietic recovery following lethal irradiation and syngeneic bone marrow transplantation Fujii, Y.;Imamura, M.;Han, M.;Hashino, S.;Zhu, X.;Kobayashi, H.;Imai, K.;Kasai, M.;Sakurada, K.;Miyazaki, T.
  27. Yakugaku Zasshi v.110 Protective activities of a Chinese medicine, hochuekki-to, to impairment of hematopoietic organs and to mecrobial infection Ikeda, S.;Kaneko, M.;Kumazawa, Y.;Nishimura, C.
  28. Exp. Hematol. v.18 Effects of juzen-taiho-toh(TJ-48), a traditional Oriental medicine, on hematopoietic recovery from radiation injury in mice Ohnishi, Y.;Yasumizu, R.;Fan, H. X.;Liu, J.;Takao-Liu, F.;Komatsu, Y.;Hosoya, E.;Geed, R. A.;Ikehara, S.
  29. J. Ethnopharmacol. v.54 Recovery of the hematopoietic system by Si-Jun-Zi-Tang in whole body irradiated mice Hsu, H. Y.;Yang, J. J.;Lian, S. L.;Ho, Y. H.;Lin, C. C.
  30. Am. J. Chin, Med. v.24 Si-jun-zi-tang regulate granulocyte macrophage colony-stimulating factor secretion by human peripheral blood mononuclear cells Tseng, J.;Li, T. L.
  31. Am. J. Chin, Med. v.21 Effects of kuei-pi-tang on cellualr immunocompetence of gamma-irradiated mice Hsu, H. Y.;Hau, D. M.;Lin, C. C.
  32. Chung Kuo Chung Yao Tsa Chih v.16 The absorption of Fe, Zn, Cu in siwu, sijunzi, and Liuwei dihuang decoction by small intestine in rats Lu, G.;Yang, M.;Shen, Y.;Meng, J.
  33. INVIVO v.7 In vivo radioprotective activity of panax ginseng and diethyldithiocarbamate Kim, S. H.;Cho, C. K.;Yoo, S. Y.;Koh, K. H.;Yun, H. G.;Kim, T. H.
  34. J. Med. Pharm. Soc. for Wakan-Yaku v.3 Radioprotective effect of Chinese medicinal prescriptions in mice Hosokawa, Y.
  35. Am. J. Chin. Med. v.21 Preliminary study on the anti-radiation effect of jen-sheng-yang-yung-tang Hsu, H. Y.;Ho, Y. H.;Lian, S. L.;Lin, C. C.
  36. Am. J. Chin. Med. v.19 Preliminary study on antiradiation effect of kuei-pi-tang Hsu, H. Y.;Ho, Y. H.;Lian, S. L.;Lin, C. C.
  37. 한약조제 지침서 해설 한약위원회;조제지침연구소위원회
  38. 한약방제학 약대 한약학 교재연구회
  39. 최신 고려 인삼(성분 및 효능 편) 남기열
  40. J. Radiat. Res. v.17 Restoration of radiation injury by intraperitoneal injection of ginseng extract in mece Yonezawa, M.
  41. J. Radiat. Res. v.22 Restoration of radiation injury by ginsengⅡ. Some properties of the radioprotective substances Yonezawa, M.;Katcoh, N.;Takeda, A.
  42. J. Radiat. Res. v.26 Restoration of radiation injury by ginseng. Ⅳ. Stimulation of recoveries in CFUs and megakaryocyte counts related to the prevention of occult blood appearance in X-irradiated mice Yonezawa, M.;Katoh, N.;Takeda, A.
  43. J. Radiat. Res. v.22 Restoration of radiation injury by ginseng.Ⅰ. Responses of X-irradiated mice to ginseng extract Takeda, A.;Yonezawa, M.;Katoh, N.
  44. J. Radiat. Res. v.23 Restoration of radiation injury by ginseng.Ⅲ. Radioprotetive effect of thermostable fraction of ginseng extract on mice, rats and huinea pigs Takeda, A.;Katoh, N.;Yonezawa, M.
  45. J. Radiat. Res. v.112 Modification of radiation response in mice by fractionated extracts of Panax ginseng Zhang, J. S.;Sigdestad, C. P.;Gemmell, M. A.;Grdina, D. J.
  46. In vivo v.12 Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice Kim, S. H.;Jeong, K. S.;Ryu, S. Y.;Kim, T. H.
  47. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.14 Preliminary clinical study on prevention of bone loss in postmenopausal women with kidney invigoration Shen, L.;Du, J. Y.;Yang, J. Y.
  48. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.11 Experimental study on anti-senility of the 4 famous Chinese herbs produced in Huaiqing area. Li, X. P.
  49. Cell Immunol. v.112 Determination of mitogenic properties and lymphocyte target sites of Dolichos lab lab lactin(DLA) : Comparative study with concanavalin A and galactose oxidase cell surfaed receptors Favero, J.;Miquel, F.;Dornand, J.;Mani, J. C.
  50. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.13 32 cases of postoperative osteogenic sarcoma treated by chemotherapy combined with Chinese medicinal herbs Liu. J. Q.;Wu, D. W.
  51. Am. J. Chin. Med. v.24 Si-jun-zi-tang regulate granulocyte marcrophage colony-stimulating factor secretion by human peripheral blood mononuclear cells Tseng, J.;Li, T. L.
  52. Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. v.113 Effect of traditional herbal medicine on gastric mucin against ethanol-induced gastric injury in rats Goso, Y.;Ogata, Y.;Ishhara, K.;Hotta, K.
  53. J. Pharmacobiodyn. v.7 Comparative studies of the stereoisomers of glycyrrhetinic acid on anti-imflammatory activities Amagaya, S.;Sugishita, E.;Ogihara, Y.;Ogawa, K.;Aizawa, T.
  54. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.15 A preliminary study on the pharmacology of the compound prescription huanggin tang and its component drugs Huang, L.;Ye, B.;Cai, B.;Li, K.;Liu, J.;Liu, M.
  55. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.16 Clinical and experimental study on treatment of ratavirus enteritis with qiwei baizhu powder He, S. T.;He, F. Z.;Wu, C. R.
  56. Yakugaku Zasshi v.111 Imaging analysis of antiulcer action and the active constituent of Atractyloides rhizoma Matsuda, H.;Li, Y. H.:Tanguchi, K.;Yamahara, J.;Tamai, Y.
  57. Yakugaku Zasshi v.111 The effect of crude drugs using diuretic on horse kidney(Na+＋K+)-adenosine triphosphatase Satoh, K.;Yasuda, I.;Nagai, F.;Ushiyama, K.;Akiyama, K.;Kano, I.
  58. Nippon Yakurigaku Zasshi v.87 Antitussive and expectorant effect of Asda-ama extract Imamura, N.;Misawa, M.;Kitagawa, H.;Yanaura, S.;Ishizone, H.
  59. Planta Med. v.63 Stivulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats Arai, I.;Konatsu, Y.;Hirai, Y.;Shingu, K.;Ida, Y.;Yamaura, H.;Yamamoto, T.;Kuroiwa, Y.;Sasaki, K.;Taguchi, S.
  60. Am. J. Chin. Med. v.9 Screening of the wormicidal Chinese raw drugs on Clonorchis sinensis Rhee, J. K.;Woo, K. J.;Baek, B. K.;Ahn, B. J.
  61. J. Nutr. Sci. Vitrminol. v.41 Effect of Playcodon grnadiflorum feeding on serum and liver lipid concentrations in rats with diet-induced gyperlipemea Kim, K. S.;Ezaki, O.;Ikemoto, S.;Itakura, H.
  62. Mutat. Res. v.260 A study on thd mutagenicity of 102 raw pharmaceuticals used in Chinese traditional medicine Yin, X. J.;Liu, D. X.;Wang, H. C.;Zhou, Y.