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Experimental Study Trends on the Acupuncture Moxibustion Treatment for Visceral Hypersensitivity: Based on the Data of PubMed

내장감각과민의 침구 치료에 대한 실험연구 현황: PubMed를 중심으로

  • Han, Chang Woo (Department of Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Choi, Jun-Yong (Department of Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Park, Seong Ha (Department of Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Kim, So Yeon (Department of Internal Medicine, Korean Medicine Hospital of Pusan National University)
  • 한창우 (부산대학교 한방병원 한방내과) ;
  • 최준용 (부산대학교 한방병원 한방내과) ;
  • 박성하 (부산대학교 한방병원 한방내과) ;
  • 김소연 (부산대학교 한방병원 한방내과)
  • Received : 2019.02.25
  • Accepted : 2019.03.18
  • Published : 2019.06.27

Abstract

Objectives : The aim of this study is to review the current trends in experimental studies on the acupuncture moxibustion treatment for visceral hypersensitivity. Methods : PubMed was searched for experimental studies about visceral hypersensitivity and acupuncture/moxibustion. Data were extracted and tabulated from the selected articles about experimental method, intervention, result and mechanism. Results : Total 23 articles were reviewed. Chronic visceral hypersensitivity animal model was applied in 17 studies (74%). Visceral hypersensitivity was measured by abdominal withdrawal reflex scoring or/and abdominal electromyogram. Acupoints like ST25, ST36, ST37, BL25, LI11, BL32 and PC6 were treated by electroacupuncture or moxibustion. All articles reported that electroacupuncture or moxibustion treatment is significantly effective in reducing visceral hypersensitivity. Treatment mechanisms were studied, related to mast cell, serotonin (5-HT) and receptor (5-HT3R and 5-HT4R), substance P (SP), vasoactive intestinal polypeptide (VIP), c-fos positive cell, corticotropin-releasing hormone (CRH), purinergic 2X (P2X)2, P2X3, P2X4, P2X7, N-methyl-D-aspartate (NMDA) receptor (NR1 and NR2B), prokinectin (PK) 1 and PK2. Conclusions : Evidences on acupuncture/moxibustion treatment for visceral hypersensitivity in animal studies warrant more research on effective acupoins, electro-acupuncture methods and treatment durations.

Acknowledgement

Supported by : Pusan National University

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