As a countermeasure to reach self-sufficiency for wood supply and demand, we have to develop wood substitutes. Rice hull is the cheapest fiber material we can get in Korea, What is better the yield of rice hull amounts to 1 million tons per year. Before carrying out this study, new ecomaterial rice hull board for housing materials was developed successfully. In order to evaluate whether the rice hull board with or without bioceramic treatment is suitable for housing materials, we studied the environmental effect of the above materials in comparison with the polycarbonate, stainless, or concrete on the adaptation (body weight, water/feed consumption, general signs, urinalysis, autopsy, etc) and the reproduction(litter size, newborn adaptation, etc)of mice. In conclusion, the concrete cage was the worst in the adaptation and so was the stainless steel cage in the reproduction. The rice hull board cage with or without bioceramic treatment was superior or equivalent to other material cages from the standpoints of the adaptation and reproduction.