• 제목, 요약, 키워드: Filler

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Hyaluronidase: An overview of its properties, applications, and side effects

  • Jung, Hyunwook
    • Archives of Plastic Surgery
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    • v.47 no.4
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    • pp.297-300
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    • 2020
  • Hyaluronidase, an enzyme that breaks down hyaluronic acid, has long been used to increase the absorption of drugs into tissue and to reduce tissue damage in cases of extravasation of a drug. With the increasing popularity of hyaluronic acid filler, hyaluronidase has become an essential drug for the correction of complications and unsatisfactory results after filler injection. For this reason, when performing procedures using hyaluronic acid filler, a sufficient knowledge of hyaluronidase is required. In order for hyaluronidase to dissolve a hyaluronic acid filler, it must interact with its binding sites within the hyaluronic acid. The reaction of a filler to hyaluronidase depends on the hyaluronic acid concentration, the number of crosslinks, and the form of the filler. Hyaluronidase is rapidly degraded and deactivated in the body. Therefore, in order to dissolve a hyaluronic acid filler, a sufficient amount of hyaluronidase must be injected close to the filler. If the filler is placed subcutaneously, injection of hyaluronidase into the filler itself may help, but if the filler is placed within a blood vessel, it is sufficient to inject hyaluronidase in the vicinity of the vessel, instead of into the filler itself. Allergic reactions are a common side effect of hyaluronidase. Most allergic reactions to hyaluronidase are local, but systemic reactions may occur in infrequent cases. Since most allergic responses to hyaluronidase are immediate hypersensitivity reactions, skin tests are recommended before use. However, some patients experience delayed allergic reactions, which skin tests may not predict.

필러 시술 금기와 제품 사용설명서에 대한 고찰 (An Overview of the Package Insert and Contraindications of Filler Products in Korea)

  • 안봉균;이수근;김혜리;김혜성
    • 대한피부과학회지
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    • v.55 no.7
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    • pp.389-393
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    • 2017
  • Filler injection is an extremely popular cosmetic procedure in Korea, but surprisingly few dermatologists are aware of the package inserts in filler products. In the era of legal dispute, it is important that we fully understand the indications, contraindications, and side effects of the individual filler products. The purpose of this paper is to provide a general overview of the contents of package inserts of filler products that are commercially available in Korea, especially in terms of the contraindications of filler injection. The authors emphasize that greater improvement in the Korean package inserts of filler products can be expected. Currently, practicing physicians are usually blamed for filler complications. We also found many significant translational errors. We hope that dermatologists take more interest in filler package inserts by reading this overview.

Mechanical and Thermal Behavior of Polyamide-6/Clay Nanocomposite Using Continuum-based Micromechanical Modeling

  • Weon, Jong-Il
    • Macromolecular Research
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    • v.17 no.10
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    • pp.797-806
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    • 2009
  • The mechanical and thermal behaviors of polyamide-6/clay nanocomposites were studied using the continuum-based, micromechanical models such as Mori-Tanaka, Halpin-Tsai and shear lag. Mechanic-based model prediction provides a better understanding regarding the dependence of the nanocomposites' reinforcement efficiency on conventional filler structural parameters such as filler aspect ratio ($\alpha$), filler orientation (S), filler weight fraction (${\Psi}_f$), and filler/matrix stiffness ratio ($E_f/E_m$). For an intercalated and exfoliated nanocomposite, an effective, filler-based, micromechanical model that includes effective filler structural parameters, the number of platelets per stack (n) and the silicate inter-layer spacing ($d_{001}$), is proposed to describe the mesoscopic intercalated filler and the nanoscopic exfoliated filler. The proposed model nicely captures the experimental modulus behaviors for both intercalated and exfoliated nanocomposites. In addition, the model prediction of the heat distortion temperature is examined for nanocomposites with different filler aspect ratio. The predicted heat distortion temperature appears to be reasonable compared to the heat distortion temperature obtained by experimental tests. Based on both the experimental results and model prediction, the reinforcement efficiency and heat resistance of the polyamide-6/clay nanocomposites definitely depend on both conventional (${\alpha},\;S,\;{\Psi}_f,\;E_f/E_m$) and effective (n, $d_{001}$) filler structural parameters.

세포외기질(ECM) 생체소재 기반 필러 개발 연구 (Development of Extracellular Matrix (ECM) based Dermal Filler)

  • 김나현;박상혁
    • 대한의용생체공학회:의공학회지
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    • v.40 no.4
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    • pp.137-142
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    • 2019
  • Numerous efforts are being made to develop an ideal dermal filler that should be bio-compatibility, non-immunogenicity, long-lasting and biodegradable without a toxic secretion. Biomaterials of dermal fillers are hyaluronic acid filler, calcium filler, PMMA filler and collagen filler depending on the ingredient. Although hyaluronic acid (HA) is most widely used, it has shortages such as short shelf life and low mechanical strength compare to extracellular matrix (ECM). The cartilage ECM composed of collagen type II, proteoglycans, glycosaminoglycans (GAGs) and in a minor part with glycoproteins. In this study, we developed a cartilage ECM injectable filler capable of improving biocompatibility and longevity compared with hyaluronic acid (HA) fillers. The ECM hydrogel was cross-linked by the reaction of N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) for mechanical enhancement. Prepared ECM filler was compared with cross-linked HA by butanediol diglycidyle ether (BDDE), which is the most widely used natural polymers for dermal filler. In the results, the articular cartilage ECM hydrogel has great potential as a dermal filler to improve the biophysical and biological performance.

자동차 알루미늄 필라튜브의 특성평가 (Characteristic Evaluation of Aluminium Filler Tube of Automotive)

  • 김해지;이운령
    • 한국기계가공학회지
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    • v.9 no.5
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    • pp.34-39
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    • 2010
  • The characteristic evaluation of an aluminium filler tube for automotive is presented in this paper. The material of filler tube was used AL3003 aluminium. In characteristic evaluation of an aluminium filler, we measured the corrosion, chemical resistance, weight, leak, welding strength, exciting endurance, and the solt spray test etc.. It has been shown that the weight decreased approximately 61% in aluminum filler tube developed comparing with steel filler tube. As the characteristic evaluation on the manufactured aluminium filler it was enough satisfied to use at the automotive filler tube.

Preparation and Properties of the Fast-Curing γ-Ray-Shielding Materials Based on Polyurethane

  • Ni, Minxuan;Tang, Xiaobin;Chai, Hao;Zhang, Yun;Chen, Tuo;Chen, Da
    • Nuclear Engineering and Technology
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    • v.48 no.6
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    • pp.1396-1403
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    • 2016
  • In this study, fast-curing shielding materials were prepared with a two-component polyurethane matrix and a filler material of PbO through a one-step, laboratory-scale method. With an increase in the filler content, viscosity increased. However, the two components showed a small difference. Curing time decreased as the filler content increased. The minimum tack-free time of 27 s was obtained at a filler content of 70 wt%. Tensile strength and compressive strength initially increased and then decreased as the filler content increased. Even when the filler content reached 60 wt%, mechanical properties were still greater than those of the matrix. Cohesional strength decreased as the filler content increased. However, cohesional strength was still greater than 100 kPa at a filler content of 60 wt%. The ${\gamma}$-ray-shielding properties increased with the increase in the filler content, and composite thickness could be increased to improve the shielding performance when the energy of ${\gamma}$-rays was high. When the filler content was 60 wt%, the composite showed excellent comprehensive properties.

저압다심케이블에서 충진물(개재물)이 절연저항에 미치는 영향 분석 (The Analysis of change of insulation resistance by filler on low voltage multi core cables)

  • 고영훈;박의석
    • 대한전기학회:학술대회논문집
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    • pp.71-72
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    • 2007
  • The insulation is a important part of cable. In thisb paper, measured the insulation resistance for analysing of change of insulation resistance by filler on low voltage multicore cables. The insulation resistance is not effected by only insulation material, but also filler material. The insulation resistance is different with measuring before filling and after filling by filler. When develope the new filler or cable, the volume resistance of filler must be considered.

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반도체 패키지 봉지재용 에폭시 수지 조성물의 신뢰특성에 미치는 실리카 고충전 영향 (Effect of High Filler Loading on the Reliability of Epoxy Holding Compound for Microelectronic Packaging)

  • 정호용;문경식;최경세
    • 마이크로전자및패키징학회지
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    • v.6 no.3
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    • pp.51-63
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    • 1999
  • 무기 충전제를 고충전시킨 에폭시 수지 조성물이 반도체 패키지의 신뢰성에 미치는 영향을 검토하였다. Ouchiyama 등의 모델로부터 최대충전밀도를 향상시킴으로써 고충전을 달성할 수 있는 방법을 제시할 수 있었으며, 최대충전밀도가 증가함에 따라 에폭시 수지 조성물의 점도가 감소하였고, 흐름성이 개선되었다. 충전제 함량이 증가함에 따라 흡습 특성이 향상되었고 열팽창계수를 낮춤으로써 저응력화를 달성할 수 있었으나, 임계 충전제 함량 이상에서는 금속 리드프레임과의 접착강도가 저하되었다. 따라서 에폭시 수지 조성물의 균형 있는 신뢰 특성을 얻기 위해서는 충전제 함량을 적정하게 선택해야 하며, 충전량을 더욱 높여 고신뢰성을 얻기 위해서는 최적의 충전제 조합을 선정하여야 함을 알 수 있었다.

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충전제 종류 및 배합비가 클로로프렌고무의 물성에 미치는 영향 (Effects of Filler Types and Compositions on the Physical Properties of Chloroprene Rubber)

  • 김덕준;이영관;최상순;김태호
    • Elastomers and Composites
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    • v.32 no.5
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    • pp.295-301
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    • 1997
  • The effects of filler types and compositions on the final properties such as tensile strength, % elongation, hardness, and specific gravity of chloroprene rubber were investigated. The fillers involved in this investigation were HAF-type carbon black, Mistron, and white clay, For each filler, the variation of filler compositions gave almost the linear effects on the all properties investigated. For a fixed filler composition, different filler types gave different influential strength on rubber properties. After linearlization of experimental data with respect to each filler composition, the simple linear addition of each property with respect to filler compositions was applied to predict the final properties of the filler included rubber systems. For the chloroprene rubber system including the fillers composed of Mistron(25phr)/HAF(20phr)/clay(35phr), the predicted properties were well in accordance with the experimental results. Similar results were obtained for other additives such as processing oil and accelerator.

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Nylon-Inorganic Filler Alloy상의 니켈 도금 기술 (Nickel Plating Techniques of Nylon-Inorganic Filler Alloy)

  • 노윤찬
    • 공업화학
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    • v.10 no.1
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    • pp.67-72
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    • 1999
  • Nylon-inorganic filler alloy의 도금에 있어 최적 전처리 공정에 관하여 연구하였다. Nylon-inorganic filler alloy는 etching 공정만으로도 무정형층을 제거하여 요구되는 충분한 밀착력을 얻을 수 있었다. SEM과 표면조도 측정으로부터 etching 공정이 수지표면을 매우 거칠고 접착력을 우수하게 만든다는 결과를 얻었으며, 도금물질의 표면상태와 접착력은 Nylon-inorganic filler alloy 수지의 성형조건에 의존한다는 것을 확인하였다. EDS 분석으로 전처리 후 수지표면의 잔류금속의 종류와 양을 측정한 결과 Cr은 Sn과 Pd의 흡착에 크게 영향을 미치지 않는 것으로 나타났다.

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