We have treated polymer surfaces such as polyethylene, polystyrene and polyester by various physicochemical and biological surface modification methods to be suitable for cell adhesion. The physicochemical methods we used were $O_2$ plasma discharge, corona discharge, sulfuric acid and chloric acid treatments. For the biological treatments, blood proteins such as plasma protein, serum protein and fibronectin were adsorbed onto the polymer surfaces. Chinese Hamster Ovary (CHO) cells were cultured on the surface-modified polymers and the cell-compatibility of those surfaces were compared. The chloric acid and fibronectin treatments were found to be the best methods of rendering the polymer surfaces adhesive for CHO cells.

Polyurethane surface was chemically modified to have different hydrophilic polyethyleneoxide(PEO)/hydrophobic dodecanediol(DDO) groups and negatively charged sulfonate group to investigate the effect to the antithrombogenicity. The hydrophilicity of the surface was significantly increased after PEO grafting or sulfonation. Lowering in-vitro platelet adhesion led to a prologation in the ex-vivo occlusion time. Especially, the sulfonated PU-PEO surface showed most enhanced blood compatibility due to the synergistic effects of PEO and $SO_3$ groups.

The graft copolymer of chitosan with amino acid, L-lysine was synthesized by heterogeneous copolymerization and was evaluated as an artificial skin. The mechanical properties under dry and wet state, water content, water vapor transmittance rate and biodegradability were measured. The tensile strength and elongation under wet state ranged $0.3-0.5\;kg/mm^2$, 10-13%, respectively. Water vapor transmittance rate ranged $450-500\;g/m^2{\cdot}day$ like that of the normal skin. The weight loss of prepared membrane by protease IV was measured for the degree of biodegradation. The degree of biodegradation was around 15% and after 4 days it was slow. Biocompatibility was evaluated by studying the attachment of human fibroblast on the prepared membrane surface.

A preliminary study has been conducted to demonstrate the effect of laser heat treatment on Ni Ti alloy dental arch wires ($0.016"\;{\times}\;0.022"$ and $0.018"\;{\times}\;0.026"$, rectangular shape). Changes in mechanical and thermal properties and surface morphologies are investigated by using optical and scanning electron microscope (SEM), energy dispersive x-ray microprobe analysis(EDX), differential scanning calorimeter (DSC), and micro hardness tester. The results indicate that the laser can affect the thermal equilibrium state of the localized surface. Titanium rich surface film is formed by the laser treatment. The surface film and rapidly resolidified underlying structures show better chemical resistance than the matrix material. Phase transition temperatures which are related to shape recovery temperatures are changed after laser treatment. Hardness of resolidified area and heat affected zone are lower than before treatment.

Prolongation in QT corrected interval (QTc), measured in surface ECG, has been shown in the majority af patients to be marker of bad prognosis in postmyocardial infarction patients (PMIP). Hence it would seem logical that dynamic QTc interval measurement can be a very usefull indicator to stratify prognosis in PMIP. We present a new algorithm for QT as well as for QTP (distance value from Q wave onset to T wave peak) intervals measurement in 24 hour ECG Holter tapes. Validation of the algorithm by hand measurement has been done on first beats of 18 Holter tapes, resulting in a magnitude of deviations between 10 and 15 ms. Application on 24 hour Holter ECG signal has also been done.

This paper presents a new algorithm for P-wave detection in the ECG signal. We detect the peak and valley point using significant point extraction algorithm with 9-point derivative. Because P-wave duration is changed according to heart-rates, we search for the R-peak and calculate the R-R interval time prior to the determination of P-wave duration threshold values in order to actively adapt to the change of P duration. We determine the parameters for P-wave detection and then P-peak, P-onset and P-offset are detected by these parameters. The results obtained from the proposed algorithm have detected successively P-wave almost more than 90%.

This paper represents a syntactic peak detection algorithm which detects peaks in the ECG signal. In the algorithm, the input waveform is linearly approximated by "split-and-merge" method, and then each line segment is symbolized with primitive set. The peeks in the symbolized input waveform are recognized by the finite-state automata, which the deterministic finite-state language is parsed by. This proposed algorithm correctly detects peaks in a normal ECG signal as well as in the abnormal ECG signal such as tachycardia and the contaminated signal with noise.

This paper describes the automatic recognition technique for heart enlargement diagnosis with the chest X-ray films enhanced by digital image processing. The technique measures a maximum transverse of the daiphragm and a maximum transverse of the heart by means of direction signature algorithms, then calculates the desired ratio of these two measured values. This is often refered to a cadiothoracic ratio which gives as useful clue for heart enlargement symptom. The experiment results in this paper show presented method is more efficient than the manual diagnosis method of the symptom.

In conventional line scan angiography, flow signal has been enhanced by the time_of_flight effect while the signal from stationary tissues has been suppressed by the saturation rf pulse followed by spoiling gradients. Due to the inhomogeneous rf field and the tissue dependent T1 relaxation time, however, stationary tissues can not be suppressed completely or uniformly, and the remnant stationary signal deteriorates the resultant angiogram. Here, the complete cancellation of stationary tissues is made possible by the spectral analysis of a series of repetitive line images of the same slice. The Fourier transformation of a set of line images results in the spectrum images, where stationary tissues are collected into the dc component while arteries are included in harmonic components because of the variation of the flow velocity and the resultant flow signal in arteries according to the cardiac cycle. The summation of harmonic components excluding the dc component results in the angiogram of arteries with the complete cancellation of stationary tissues.

300 MHz proton NMR spectra of human blood plasma were analyzed by deconvolution of spectrum, and we compared its results with Fossel's test in normal (15 cases), liver cancer (14 cases) , and other cancer (14 cases) groups. This analysis had enabled us to obtain dynamic characteristics of each individual lipoprotein. As a result of deconvolution method, the VLDL and chylomicron intensity level were found to be elevated in the patients with liver cancer. Moment ratio values of $CH_2$ resonance in the raw spectrum were found to be higher than the normal group for patients with, malignant tumors other than liver cancer. These differences between the three groups could not be found in the conventional Fossel's test. We could simulate plasma spectra by addition of spectra of individual lipoproteins through deconvolution method. Further clinical trials in larger populations and additional biochemical method may shed new light on many of clinical and biochemical interests for knowing characteristics about lipoprotein not separated from blood and the background of Fossel test.

A new MR angiography technique using a composite sequence for the suppression of static sample signals is proposed and verified with experiments. When the composite [$90^{\circ}-{\tau}-180^{\circ}-2{\tau}-180^{\circ}-{\tau}$] sequence is applied, the large signal from the static sample is sufficiently suppressed but the signal from fresh inflow sample of which amplitude. is observed without suppression. These properties are appropriate for angiographic applications. In this paper, a modified line scan method (Block line scan angiography) incorporated with the composite [$90^{\circ}-{\tau}-180^{\circ}-2{\tau}-180^{\circ}-{\tau}$] sequence is used to obtain flow-only images, i.e., angiograms. The block line scan method improves the resolution in the flow-direction at the expense of imaging time. With the composite sequence, there is no need for subtraction procedure as in the most conventional angiographic methods. Experimental results for a phantom and a normal volunteer with KAIS 2.0 Tesla MRI system are shown.

In this paper, hierachical representation method with a 1-to-4 and 1-to-8 data structure is used to reconstruct the three-dimensional scene from two-dimensional cross sections provided by computed tomography with small memory computer system. To reduce the internal memory use, 2-D section is represented by quadtree, and 3-D scene is represented by octree. Octree is constructed by recursively merging consecutive quadtrees. This method uses 7/200 less memory than pointer type structure with all the case, and less memory up to 60.3% than linear octree with experimental data.

In this paper the feature of background EEG is extracted by LS Prony Method for the analysis of background EEG in the time domain. From the experimential results the alpha band amplitude is the largest among bands and beta band amplitude is larger than that of the delta band and theta band. The sustained time for the alpha band, the beta band, the delta band and the theta band is 2.3461(sec), 1.8980(sec), 0.3120(sec), 0.2930(sec) respectively. Consequently the alpha band and the beta band are maintained in the whole, segment. The delta band, the theta band are existed intermittently in the segment.

지난 몇년동안 생체에서의 MR 스펙트로 스코피(Mangetic Resonance Spectroscopy)를 위하여 ISIS, VSE, SPARS, STEAM 등과 같은 여러 체적 선택의 방법이 연구되어 왔다. 그러나 이들 3차윈 체적 선택의 방법은 여러 RF 펄스를 사용하여야 되었으며 상대적으로 오랜시간 동안의 RF여기시간(Radio frequency excitation time) 때문에 T1과 T2 감소효과의 영향을 크게 받았다. 본 논문에서는 3차원의 체적을 선택하기 위하여 단일 RF펄스의 사용을 제안하고 있는데, 이 방법은 원통형 체적을 선택하기 위한 방사형 경사 코일 (a radial gradient coil) 방법과 진동자계 (oscillating selection gradient) 방법을 결합하고 있다. 이렇게 하므로 단일 RF 펄스만을 사용하여 체적 선택 시간을 최소화하여 여러 RF 펄스를 사용할 경우 발생하는 파생적인 에코 신호(echo signal)를 피할 수 있었다. 제안된 방법에 의한 실험적 연구결과로서 펜톰(phantom)에 대하여 선택된 체적에 대한 영상과 스펙트럼 (spectrum)을 제시하였다.

A true three-dimensional cone-beam reconstruction (TTCR) algorithm for the complete sphere geometry is derived, which is applicable to the direct volume image reconstruction from 2-D cone-beam projections. The algorithm is based on the modified filtered backprojection technique which uses a set of 2-D space-invariant filters and is derived from the previously developed parallel-beam true three-dimensional reconstruction(TTR) algorithm. The proposed algorithm proved to be superior in spatial resolution compared with the parallel-beam TTR algorithm.

In this paper, a method of the measument the degree of the musule fatigue by Short Time Fourier Analysis of the EMG signals from human biceps in the action state is proposed. For this purpose, fatigue state and recovery state of 10 persons EMG signals are sampled. And then spectrum centroids are analyzed with respect to the change of sample time window. As result of 10 persons experiment, we know that person A is most good recovery stale.

In this paper, principles of Rhcoencephalography(RBG) was described and RBG was designed and developed. Using the developed instrument, RBG waveforms of the left and right brain, RBG waveform changes by posture, were observed. It was found that RBG waveforms could be observed noninvasively. RBG can be easily applied for testing the effect of various drugs related to CBF(Cerebral blood flow) since it is quite sensitive to the relative changes of CBF. Various cerebral diseases can be diagnosed by analyzing the RBG waveforms. The area of restricted cerebral blood vessels can be located by arranging the appropriate electrode configuration.

The origins of the motion artifact resulting from exercise in impedance cardiography wore explained and the ensemble average technique was applied to reduce the motion artifact enabling the measurement of cardiac output during exercise. Algorithm for ensemble average was developed and applied to the actual impedance signals. It was found that the minimum number of sampling was 20, and sampling frequency was 500Hz. Using the ensemble average technique it was possible to measure cardiac output continuously during the treadmill exercise. Therefore it is hoped that this study may contribute in the area of exercise physiology and sport medicine.

The blood bank is a field of clinical pathology which requires the most accuratemaintenanceofrecording. Because the mistake in it is directly related to a patient's life. So, the computerization of the blood bank is urgent to maintain a log blook arid to compare the patient's current data with past result. We developed the blood bank management program using 32 bit minicomputer. This is composed of 4 parts; a management of routine test result, special test result, the blood issue and statistics. The management of routine test result handles the patient's information and blood typing and compares above results with the past one of same patient. The management of special test result are for special immunohematologic tests like an irregular antibody, Coombs' test, and etc. Blood issue part records the type of the blood bag, component, and the name of issuer. Statistic part are made to get statistics of each day and each month by the blood type, and the type the blood component. The program is secured by the maintenance of operator's operation history and thu provision of the security code to each operator, without which no one can enter the system and after the content. So the stability and reliability of the data is obtained. This program will be upgraded for bar-code using system in the near future.

This paper describes a study on the locomotion control system for a indoor-use mobile wheelchair. Three lode of operations - BASIC, AUTOMATIC and PROGRAMMED - are employed as basic algorithm building block. One-chip microcomputer 8031 is dominating the control of actuation part and it can control the range of rotating speed of the wheel both right and left by servo motor. Keyboard is employed as a command input device. This system is intended to improve the daily life of the disabled by the intelligent interactive operation scheme.

In surgery the hemostatic control is very important for the parenchymatous organs. These organs consist of the fragile and the blood content tissues such as liver, spleen and kidney, etc.. One of the control methods to solve this problem is to insert the mono polar typed needle electrode, which gathers the thermal effect of microwave, directly into tissues so as to coagulate and stop the hemorrhage. This method has same advantages: First, the range of the heat energy is limited. Second, the coagulation, the hemostatic characteristic, and stability are excellent. Third, more convenient operation is possible. This paper is aimed to manufacture the microwave tissue coagulation system and to suggest the new direction for development, hereafter.