In summary, air pollution issues in the United States are addressed by a core group of regulations supplemented by active Interventions as needed by public health agencies. The strategies employed by public health officials must be flexible and innovative to address the needs of the citizens, As you can see from the examples cited above, the collaboration of public health agencies can be critical in protecting communities from adverse exposures. In the US state and local governments have the primary responsibility for health and safety issues, including those associated with air pollution. The federal agencies have responsibilities when activities between states are involved and or the issues are of national significance. Significant challenges and opportunities remain to identify the relationship to air pollution and other environmental factors and the incidence of disease, and hence develop and implement Intervention strategies.